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Table 1 Host factors and urine LAM Status of 199 study participants

From: Lipoarabinomannan in urine during tuberculosis treatment: association with host and pathogen factors and mycobacteriuria

Host Factors

Total n = 199

LAM Negative

n = 167 (83.9%)

LAM Positive*

n = 32 (16.1%)

p-value**

Median age years [IQR]

34 [28-43]

35 [30-40]

34 [28-44]

0.929†

Gender

   

0.904††

Male

110

92 (55.1)

18 (56.3)

 

Female

89

75 (44.9)

14 (43.8)

 

Patient TB category

   

0.968††

New TB case

125

105 (62.9)

20 (62.5)

 

Re-treatment TB case

74

62 37.1)

12 (37.5)

 

Site of disease

   

0.613‡

Pulmonary

168

141 (84.4)

27 (84.4)

 

Extra-Pulmonary

18

16 (9.6)

2 (6.3)

 

Pulmonary and Extra-Pulmonary

13

10 (6)

3 (9.4)

 

Smear or culture positive

   

< 0.001‡

Positive

119

90 (53.9)

29 (90.6)

 

Negative

79

76 (45.5)

3 (9.4)

 

Not done

1

1 (0.6)

0 (0)

 

HIV status

   

0.002‡

Positive

146

117 (70.1)

29 (90.6)

 

Negative

52

50 (29.9)

2 (6.3)

 

Unknown

1

0 (0)

1 (3.1)

 

Median CD4 cells/μL. [IQR] a

132.5 [70-283]

156 [80-309]

95 [42-134]

0.006†

< 50

26

17 (14.5)

9 (31)

 

50-99

28

22 (18.8)

6 (20.7)

 

100-199

39

31 (26.5)

8 (27.6)

 

≥ 200

53

47 (40.2)

6 (20.7)

 

ART at start of TB treatment a

   

0.078††

Yes

33

30 (25.6)

3 (10.3)

 

No

113

87 (74.4)

26 (89.7)

 
  1. *LAM positive patients are defined as those who were LAM positive on day 1 or on two or more occasions during TB treatment. A LAM result was considered positive when the average sample LAM-ELISA optical density (OD) minus the negative control was greater than or equal to 0.1 and negative when the average sample OD minus the negative control was less than 0.1. **p-values indicate differences between LAM positive and LAM negative participants. p-values were calculated using Wilcoxon rank sum†, chi-square††, and Fisher's exact test‡ . aof the 146 HIV positive subjects