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Table 1 M.tb target antigens used for T cell stimulation

From: Pattern recognition and cellular immune responses to novel Mycobacterium tuberculosis-antigens in individuals from Belarus

M.tbtarget protein



Cyclopropane fatty acyl phospholipid synthase


Involved in lipid formation and synthesis of long fatty acids, resistance to (oxidative) stress and survival

Mycobacterium bovis mycocerosic acid synthase gene (mas)


(mas) multifunctional enzyme that catalyzes the synthesis of very long chain multiple methyl branched fatty acids called mycocerosic acids present in slow-growing pathogenic mycobacteria, major mycobacterial cell wall complex

PPE family proteins


Accounts for about 10% of the genomic M.tb coding capacity. Form a source for antigenic variation among different M.tb strains


Rv1917c (p)

Induces functional maturation of dendritic cells through an integrated cross talk between PI3K-MAPK and NF-κB signaling cascades and facilitates a Th2 phenotype

PE_PGRS 11 family proteins

Rv0754 (p) Rv0978c (p)

Cell wall associated protein, induces activation and maturation of human dendritic cells as well as secretion of key proinflammatory cytokines

Probable molybdopterin-guanine dinucleotide biosynthesis protein


Involved in metabolism and respiration, associated with non replicating bacteria

Secreted antigen 85A and 85B

Hypotheticall cell wall protein

Rv3804c (85A) (p)

Rv1886c (85B)

(both as peptides and protein)


Mycolyl transferase activity. Responsible for the high affinity of mycobacteria to fibronectin

Cell- wall associated protein

Probable lipoprotein LPRJ


Contains possible signal sequence and a prokaryotic membrane lipoprotein lipid attachment site

Secreted ESAT-6 like protein ESXH (TB10.3)



Rv3875 (p)

M.tb pathogenicity

Possible glycosyl transferase

Rv2957c, Rv2958c Rv2962c

cellular metabolism and lipid formation, contributes to M.tb survival in macrophages

Possible hemolysin -like protein


virulence and adaption

Probable isocitrate dehydrogenase


cellular metabolism

Low molecular weight protein antigen 7 esxH

Rv0288 (TB10.4) peptides and protein

bacterial virulence

  1. List of M.tb target antigens used for T-cell stimulation. Proteins are designated with (p) unless stated otherwise