M.tbtarget protein | ID | Biology |
---|---|---|
Cyclopropane fatty acyl phospholipid synthase | Rv0447c | Involved in lipid formation and synthesis of long fatty acids, resistance to (oxidative) stress and survival |
Mycobacterium bovis mycocerosic acid synthase gene (mas) | Rv2940c | (mas) multifunctional enzyme that catalyzes the synthesis of very long chain multiple methyl branched fatty acids called mycocerosic acids present in slow-growing pathogenic mycobacteria, major mycobacterial cell wall complex |
PPE family proteins | Rv3347c | Accounts for about 10% of the genomic M.tb coding capacity. Form a source for antigenic variation among different M.tb strains |
 | Rv1917c (p) | Induces functional maturation of dendritic cells through an integrated cross talk between PI3K-MAPK and NF-κB signaling cascades and facilitates a Th2 phenotype |
PE_PGRS 11 family proteins | Rv0754 (p) Rv0978c (p) | Cell wall associated protein, induces activation and maturation of human dendritic cells as well as secretion of key proinflammatory cytokines |
Probable molybdopterin-guanine dinucleotide biosynthesis protein | Rv2453c | Involved in metabolism and respiration, associated with non replicating bacteria |
Secreted antigen 85A and 85B Hypotheticall cell wall protein | Rv3804c (85A) (p) Rv1886c (85B) (both as peptides and protein) Rv0959 | Mycolyl transferase activity. Responsible for the high affinity of mycobacteria to fibronectin Cell- wall associated protein |
Probable lipoprotein LPRJ | Rv1690 | Contains possible signal sequence and a prokaryotic membrane lipoprotein lipid attachment site |
Secreted ESAT-6 like protein ESXH (TB10.3) ESAT-6 | Rv3019 Rv3875 (p) | M.tb pathogenicity |
Possible glycosyl transferase | Rv2957c, Rv2958c Rv2962c | cellular metabolism and lipid formation, contributes to M.tb survival in macrophages |
Possible hemolysin -like protein | Rv1085c | virulence and adaption |
Probable isocitrate dehydrogenase | Rv0066c | cellular metabolism |
Low molecular weight protein antigen 7 esxH | Rv0288 (TB10.4) peptides and protein | bacterial virulence |