Additional risk factors for infection by multidrug-resistant pathogens in healthcare-associated infection: a large cohort study

Table 3 Independent variables associated with infection by MDR, MDR gram-negatives and pathogens from the ESKAPE group

Variables	MDR, n (%) n = 123	Adjusted OR	CI_95%	p-value	MDR Gram negatives, n (%) n = 104	Adjusted OR	CI_95%	p-value	ESKAPE pathogens, n(%) n= 41	Adjusted OR	CI_95%	p-value
Age		1.7	1.3-2.3	0.001		1.5	1.1-2.1	0.009
≤60 years	33 (27)				30 (28)				13 (32)
61-80 years	44 (36)				37 (36)				13 (32)
>80 years	46 (37)				37 (36)				15 (36)
Previous antibiotic therapy	38 (31)				30 (29)				20 (49)	7.2	3.1-17.0	<0.001
Hospitalization in the previous year (4 months - 1 year)	37 (30)	2.0	1.2-3.4	0.008	29 (28)	1.7	1.0-3.0	0.048	14 (34)
Karnofsky index<70	57 (46)				44 (42)				22 (54)	3.7	1.6-8.6	0.003

Selection of variables significantly and independently associated with infection by a MDR pathogen, MDR gram negative or a pathogen from the ESKAPE group, among the group of patients admitted from the community (with community or healthcare-associated infection), using multiple logistic regression.
*increase in the odds per category of age; MDR – multi-drug resistant; OR – odds ratio; CI – confidence interval; ESKAPE - Vancomycin-resistant Enterococcus faecium, MRSA, ESBL producing E. coli and Klebsiella species, Klebsiella pneumonia Carbapenamase-hydrolyzing and MDR Acinectobacter baumannii, Pseudomonas aeruginosa and Enterobacter species.

ISSN: 1471-2334