Table 1 Key Parameters for Cost-Effectiveness Analysis

Epidemiologic/Diagnostic/Treatment Parameters

Lifetime LTBI progression to active TB

5%

1%

15%

[12, 13]

Percent of LTBI referrals that are foreign-born

64%

30%

100%

[4]

Percent of QFT-GIT positivity in BCHD

57% FB; 36% US

--

--

BCHD, [4]

Prevalence of LTBI in TST-positive referrals

70% FB; 43% US

0%

100%

Calculated;[4]

Sensitivity of QFT-GIT

81%

36%

100%

[8, 9, 14]

Specificity of QFT-GIT

99%

90%

100%

[8]

Percent of LTBI patients treated with 4Rif

62%

0%

100%

BCHD

LTBI treatment completion for 9INH (4Rif)

52% (73%)

25%

100%

BCHD, [15, 16]

Drug-induced liver injury (percent severe)

1% (0.002%)

0%

6%

BCHD, [13, 15, 17–20]

Efficacy of LTBI treatment medications

0.9

0.50

1

[3, 17, 21, 22]

QFT-GIT Costs

2012 US$

QFT-GIT tubes

$7.10/test

$6.60

$12.42

BCHD

Phlebotomy supplies and clinic supplies

$2.18

$0.55

$3.82

BCHD

QFT-GIT kit

$23.92/test*

$9.90*

$71.75*

BCHD

QFT-GIT lab consumables

$3.50/test

$.87

$6.12

BCHD

Total equipment costs for QFT-GIT testing††

$1.14/test

$.29

$1.99

BCHD

Phlebotomist labor for QFT-GIT

$1.60/test

$1.60

$3.99

BCHD

Laboratory labor for QFT-GIT

$2.28/test

$1.48

$2.52

BCHD

Overhead for QFT-GIT testing

$0.53/sample

$0.25

$2.50

BCHD

TB Treatment Costs

Initial LTBI evaluation labor

$35.04

$15.88

$68.29

BCHD

Labor LTBI treatment: 9INH

$88.56

$36.40†

$171†

BCHD

Labor LTBI treatment: 4Rif

$44.28

$18.20†

$85.70†

BCHD

Drug costs 9INH

$26.82/course

$9.27

$91.35

BCHD

Drug costs 4Rif

$102.12/course

$102.12

$482.60

BCHD

Chest x-ray

$100

$50

$175

BCHD

Mild hepatitis

$41.62

$0

$344

BCHD, [21]

Severe hepatitis

$124.86

$41.62

$23,818

BCHD, [21]

Cost of active TB (includes drugs, staff, labs)

$8,568

$2,142

$64,195

BCHD, [20, 21, 23]

Utilities

Well

1

[21]

9INH treatment

0.95

.9

.99

[20, 21]

4Rif treatment

0.99

.9

.99

[20, 21]

Mild hepatitis

0.85

1 mo

12 mo

[20, 21]

Severe hepatitis

0.40

0.1

0.4

[20, 21]

Active TB **

0.85

0.5

0.9

[21]

Fatal TB **

0.5

0.1

0.5

[21]

Death

0

[21]