Epidemiologic/Diagnostic/Treatment Parameters
| | | | |
Lifetime LTBI progression to active TB
|
5%
|
1%
|
15%
|
[12, 13]
|
Percent of LTBI referrals that are foreign-born
|
64%
|
30%
|
100%
|
[4]
|
Percent of QFT-GIT positivity in BCHD
|
57% FB; 36% US
|
--
|
--
|
BCHD, [4]
|
Prevalence of LTBI in TST-positive referrals
|
70% FB; 43% US
|
0%
|
100%
|
Calculated;[4]
|
Sensitivity of QFT-GIT
|
81%
|
36%
|
100%
|
[8, 9, 14]
|
Specificity of QFT-GIT
|
99%
|
90%
|
100%
|
[8]
|
Percent of LTBI patients treated with 4Rif
|
62%
|
0%
|
100%
|
BCHD
|
LTBI treatment completion for 9INH (4Rif)
|
52% (73%)
|
25%
|
100%
|
BCHD, [15, 16]
|
Drug-induced liver injury (percent severe)
|
1% (0.002%)
|
0%
|
6%
|
BCHD, [13, 15, 17–20]
|
Efficacy of LTBI treatment medications
|
0.9
|
0.50
|
1
|
[3, 17, 21, 22]
|
QFT-GIT Costs
|
2012 US$
| | | |
QFT-GIT tubes
|
$7.10/test
|
$6.60
|
$12.42
|
BCHD
|
Phlebotomy supplies and clinic supplies
|
$2.18
|
$0.55
|
$3.82
|
BCHD
|
QFT-GIT kit
|
$23.92/test*
|
$9.90*
|
$71.75*
|
BCHD
|
QFT-GIT lab consumables
|
$3.50/test
|
$.87
|
$6.12
|
BCHD
|
Total equipment costs for QFT-GIT testing††
|
$1.14/test
|
$.29
|
$1.99
|
BCHD
|
Phlebotomist labor for QFT-GIT
|
$1.60/test
|
$1.60
|
$3.99
|
BCHD
|
Laboratory labor for QFT-GIT
|
$2.28/test
|
$1.48
|
$2.52
|
BCHD
|
Overhead for QFT-GIT testing
|
$0.53/sample
|
$0.25
|
$2.50
|
BCHD
|
TB Treatment Costs
| | | | |
Initial LTBI evaluation labor
|
$35.04
|
$15.88
|
$68.29
|
BCHD
|
Labor LTBI treatment: 9INH
|
$88.56
|
$36.40†
|
$171†
|
BCHD
|
Labor LTBI treatment: 4Rif
|
$44.28
|
$18.20†
|
$85.70†
|
BCHD
|
Drug costs 9INH
|
$26.82/course
|
$9.27
|
$91.35
|
BCHD
|
Drug costs 4Rif
|
$102.12/course
|
$102.12
|
$482.60
|
BCHD
|
Chest x-ray
|
$100
|
$50
|
$175
|
BCHD
|
Mild hepatitis
|
$41.62
|
$0
|
$344
|
BCHD, [21]
|
Severe hepatitis
|
$124.86
|
$41.62
|
$23,818
|
BCHD, [21]
|
Cost of active TB (includes drugs, staff, labs)
|
$8,568
|
$2,142
|
$64,195
|
BCHD, [20, 21, 23]
|
Utilities
| | | | |
Well
|
1
| | |
[21]
|
9INH treatment
|
0.95
|
.9
|
.99
|
[20, 21]
|
4Rif treatment
|
0.99
|
.9
|
.99
|
[20, 21]
|
Mild hepatitis
|
0.85
|
1 mo
|
12 mo
|
[20, 21]
|
Severe hepatitis
|
0.40
|
0.1
|
0.4
|
[20, 21]
|
Active TB **
|
0.85
|
0.5
|
0.9
|
[21]
|
Fatal TB **
|
0.5
|
0.1
|
0.5
|
[21]
|
Death
|
0
| | |
[21]
|