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Table 3 Distribution of studies by quality-scoring values according to the Chalmers et al. and Jadad et al. methods

From: Efficacy of pegylated interferon α-2a and α-2b in patients with genotype 1 chronic hepatitis C: a meta-analysis

 

Chalmers

Jadad score

First Author [Reference No.]

1

2

3

4

5

6

7

8

9

10

11

Protocol

12

13

14

15

16

17

18

19

20

21

22

Data analysis

Overall

1

2

3

Overall

Yenice [16]

1

0

1

0

0

0

0

0

0

1

0

0.17

0

1

0

0

0

0

0

1

0

0

0

0.23

0.2

1

0

0

1

Di Bisceglie [17]

1

0

1

0

0

0

0

1

1

1

n.a.

0.35

0

1

0

0

1

0

0

1

0

1

0

0.44

0.39

1

0

0

1

Escudero [18]

1

0

1

0

0

0

0

0

0

0

0

0.11

1

1

0

0

1

1

0

1

0

1

0

0.61

0.31

0

0

0

0

McHutchison [19]

1

1

1

1

0

0

0

1

1

1

0

0.58

1

1

0

0

1

1

0

1

0

1

0

0.61

0.6

2

0

1

3

Ascione [20]

1

1

1

1

0

0

0

1

1

1

0

0.54

1

1

0

n.a.

1

1

0

1

0

1

0

0.67

0.59

2

0

1

3

Lee [21]

1

0

1

0

0

0

1

0

0

1

0

0.15

1

1

0

0

0

1

0

1

0

1

0

0.54

0.37

0

0

0

0

Rumi [22]

1

1

1

1

0

0

0

1

1

1

0

0.54

1

1

0

n.a.

1

1

0

1

0

1

0

0.67

0.59

2

0

1

3

  1. For the Chalmers et al. method: 0 is “Non adequate”, 1 is “Adequate” for the following items: 1 Selection description; 2 Number and reasons for eligible patients not included in the study; 3 Regimen definition; 4 Blinding of Randomization; 5 Blinding of Patients to therapy; 6 Blinding of Physicians/observers to therapy; 7 Blinding of Physicians/observers to ongoing results; 8 Regimen definition; 9 Statistical estimate of sample size; 10 Testing randomization; 11 Testing compliance; 12 Dates of study; 13 Results of prerandomization; 14 Both test statistics and P value given; 15 Post beta estimate; 16 Confidence intervals given; 17 Regression/correlation; 18 Statistical analysis; 19 Number and reasons for patients withdrawn after randomization; 20 Withdrawals handled in several ways; 21 Side effects discussion; 22 Subgroups retrospective analysis. For the Jadad et al. the points are assigned for the following items: 1 Randomization; 2 Double-blinding; 3 Withdrawals and drop-out.
  2. n.a. not applicable.