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Table 2 Outcomes in the studies included in the meta-analysis

From: Efficacy of pegylated interferon α-2a and α-2b in patients with genotype 1 chronic hepatitis C: a meta-analysis

First Author [Reference No.]

Outcomes, n° (%) of patients in Peg-IFN α-2a/α-2b group

 

RVR

EVR

ETR

SVR

Discontinuation of therapy for adverse events in patients with genotype 1 all genotypes

Peg-IFN reduction for adverse events in patients with all genotypes

Yenice [16] #

  

28(75.7)/27(73)

18(48.6)/13(35.1)

3 (7.5)/3 (7.5)

3 (7.5)/3 (7.5)

 

Di Bisceglie [17] §

14(7.4)/22(11.5)

74(39.1)/84(43.9)

     

Escudero [18] †

15(25.4)/10(17.2)

33(55.9)/29(50)

12(20.3)/7(12.1)

30(50.8)/27(46.6)

 

12(13.1)/10(10.8)

8(8.7)/7(7.6)

McHutchison [19] $

123(11.9)/116(11.4)

466(45)/407(39.9)

667(64.4)/542(53.2)

423(40.9)/406(39.8)

135(13)/129(12.6)

135(13)/129(12.6)

264(25.5)/254(24.9)

Ascione [20] §

   

51(54.8)/37(39.8)

3 (3.2)/13 (14)

4(2.5)/22(13.7)

 

Lee [21] ^

 

16(76.2)/12(75)

16(76.2)/13(81.3)

8(38)/10(62.5)

 

8(10.1)/5(10.6)

 

Rumi [22] ç

34(37)/26(30)

60(66)/40(46)

59(65)/38(44)

44(48)/28(32)

 

16(7.5)/17(7.7)

22(10.3)/14(6.3)

  1. Dosage of ribavirin
  2. # 4064 kg of weight: 800 mg/day; 65–85 kg: 1,000 mg/day; >85 kg: 1,200 mg/day.
  3. § <75 kg of weight: 1,000 mg/day; ≥75 kg: 1,200 mg/day.
  4. † ≤65 kg of weight: 800 mg/day; 65–75 kg: 1,000 mg/day; >75 kg: 1,200 mg/day.
  5. $ In the Peg-IFN α-2b arm: 40–65 kg of weight: 800 mg/day; >65-85 kg: 1,000 mg/day; >85-105 kg: 1,200 mg/day; >105-125 kg: 1,400 mg/day. In the Peg-IFN α-2a arm: <75 kg: 1,000 mg/day; ≥75 kg: 1,200 mg/day.
  6. ^ In the Peg-IFN α-2a arm: <75 kg of weight: 1,000 mg/day; ≥75 kg: 1,200 mg/day. In the Peg-IFN α-2b arm: <65 kg: 800 mg/day; 65–85 kg: 1,000 mg; >85 kg: 1,200 mg.
  7. ç <75 kg of weight: 1,000 mg/day; ≥75 kg: 1,200 mg/day.