From: A longitudinal evaluation of Treponema pallidumPCR testing in early syphilis
Category | Breakdown | PCR- pos/ serology- pos | Sensitivity (95% CI) | PCR- neg/ serology-neg | Specificity (95% CI) |
---|---|---|---|---|---|
Lesion stage | Primary lesions(a) | 49/55 | 89.1 (77.8-95.9) | 200/202 | 99.1 (96.5-99.9) |
Secondary lesions(b) | 11/22 | 50.0 (28.2-71.8) | 9/9 | 100.0 (66.4-100) | |
Lesion site | Penile ulcer | 30/33 | 90.9 (75.7-98.1) | 68/70 | 97.1 (90.0-99.7) |
Anal ulcer | 16/16 | 100.0 (79.4-100) | 88/88 | 100.0 (95.9-100*) | |
Oral ulcer | 3/6 | 50.0 (11.8-88.2) | 44/44 | 100.0 (91.9-100) | |
Generalised rash | 6/17 | 35.3 (14.2-61.7) | 9/9 | 100.0 (66.4-100) | |
Perianal condylomata lata/snail track ulcers of the mouth | 5/5 | 100.0 (47.8-100) | - | - |