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Table 1 Performance of T pallidum PCR by syphilis stage and lesion site

From: A longitudinal evaluation of Treponema pallidumPCR testing in early syphilis

Category Breakdown PCR- pos/ serology- pos Sensitivity (95% CI) PCR- neg/ serology-neg Specificity (95% CI)
Lesion stage Primary lesions(a) 49/55 89.1 (77.8-95.9) 200/202 99.1 (96.5-99.9)
Secondary lesions(b) 11/22 50.0 (28.2-71.8) 9/9 100.0 (66.4-100)
Lesion site Penile ulcer 30/33 90.9 (75.7-98.1) 68/70 97.1 (90.0-99.7)
Anal ulcer 16/16 100.0 (79.4-100) 88/88 100.0 (95.9-100*)
Oral ulcer 3/6 50.0 (11.8-88.2) 44/44 100.0 (91.9-100)
Generalised rash 6/17 35.3 (14.2-61.7) 9/9 100.0 (66.4-100)
Perianal condylomata lata/snail track ulcers of the mouth 5/5 100.0 (47.8-100) - -
  1. (a)=penile, anal and oral ulcers.
  2. (b)= Generalised rash, perianal condylomata lata, and snail track ulcers of the mouth.