Figure 4
Effect of A 2A AR Agonist ATL1222 on Mortality of Mice Infected with C.difficile and Treated with Vancomycin of Short or Long Duration. Mice were infected with VPI10463 at 105 inoculum. Each group had 8 mice except uninfected control (n=4). A. Mice were treated or not with vancomycin (50 mg/kg/day) for 1, 2, 3 or 5 days. P=0.058 by Log-rank (Mantel-Cox) Test. B. Mice were treated with vancomycin for either 2 or 5 days with or without ATL1222 (1ng/kg/min started at day 1 post-infection). P value for Log-rank (Mantel-Cox) test at 0.29. C. Weight Change (%). D. Diarrhea score (mean). Scoring system defined in Table 1.