Effect of A
AR Agonist ATL370 on
C. difficile-Infected Mice. Mice were infected with VPI10463 at 105 inoculum and treated or not with vancomycin (50 mg/kg/day for 3 days) with or without ATL370 (1 ng/kg/min). Each group had 6 mice each except for uninfected control (n=4). For statistical analyses of weight change and clinical scores, the latest value from a dead mouse was carried through to the end of observation but not shown in the graphs. A. Survival curve. P=0.0016 by Mantel-Cox. B. Percent weight loss from day 0 (day of infection). *p<0.05 to 0.001 for uninfected (UC) vs. infected (I) controls, †p<0.01 to 0.001 for I vs I with vancomycin (Vanc), ‡p<0.01 to 0.001 for I vs. I with Vanc plus ATL370(1); by Two-way ANOVA with Bonferroni’s correction. C. Clinical scores. *p<0.05 for UC vs. I controls, †p<0.05 for I vs I with Vanc; by Two-way ANOVA with Bonferroni’s correction.