Laboratory testing for cytomegalovirus among pregnant women in the United States: a retrospective study using administrative claims data

Table 2 Type of CMV testing and timing of CMV testing among pregnant women ^a and among pregnant women ^a with a diagnostic code for CMV, MarketScan 2009

	Pregnant women^awith CMV-specific testing^b		Pregnant women^awith an ICD-9-CM diagnostic code for CMV disease and CMV-specific testing^b
	N, 1,668		N, 10
	#	%	#	%
Type of CMV-specific Test ^b
CMV PCR ONLY	17	1%	1	10%
CMV DFA ONLY	1	0%	0	0%
CMV Serology ONLY (CMV IgG, IgM, and EIA)	741	44%	5	50%
CMV PCR AND CMV Serology	8	0%	0	0%
CMV PCR AND Non-Specific Culture or PCR	24	1%	2	20%
CMV PCR, CMV Serology, AND Non-specific Culture or PCR	13	1%	0	0%
CMV DFA, CMV Serology, AND Non-Specific Culture or PCR	1	0%	0	0%
CMV Serology AND Non-specific Culture or PCR	863	52%	2	20%
Gestational Age when CMV-Specific Testing Conducted ^c
1^st Trimester	863	52%	5	50%
2^nd Trimester	395	24%	4	40%
3^rd Trimester	410	24%	1	10%

Note: CMV, cytomegalovirus; ICD-9-CM, International Classification of Diseases-9^th revision, Clinical Modification; PCR, polymerase chain reaction; IgG, Immunoglobulin G; IgM, Immunoglobulin M; DFA, direct fluorescent testing; EIA, enzyme immunoassay.
^aPregnant women defined as female enrollees who were 1) aged 15–44 years, 2) enrolled for the entire year in 2009, and 3) had a delivery code (defined in Appendix) between October-December 2009.
^bCMV-specific testing includes CMV IgG, CMV IgM, CMV DFA, CMV EIA, and CMV PCR testing.
^cDate of first claim with a delivery code (defined in Appendix) was used to approximate delivery date in order to calculate the approximate age when the first CMV-specific testing was done. We assumed that CMV-specific testing which occurred 0–13 weeks was within the 1^st trimester, testing within weeks 14–26 to be in the 2^nd trimester, and testing within weeks 27–42 to be in the 3^rd trimester. Pregnant women with testing that occurred before (<0 weeks) or after (≥43 weeks) pregnancy were excluded.

ISSN: 1471-2334