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Table 1 Differential apoptotic gene expressions of RD cells in response to EV71 infection at 8 and 20 h postinfection

From: Differential apoptosis gene expressions of rhabdomyosarcoma cells in response to enterovirus 71 infection

Symbols

Description of genes

EV71/control

  

(Fold changes)

  

8 h

20 h

ACIN1

Apoptotic chromatin condensation inducer 1 (ACINUS; ACN; fSAP152)

-3.17

1.33

AIFM1

Apoptosis-inducing factor 1 (AIF; COXPD6; PDCD8)

1.03

-1.33

AIFM2

Apoptosis-inducing factor, mitochondrion-associated, 2 (AMID; PRG3; RP11-367H5.2)

-3.83

-1.25

Akt1

V-akt murine thymoma viral oncogene homolog 1 (AKT1; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA)

-9.89

-1.13

Akt2

V-akt murine thymoma viral oncogene homolog 2 (AKT2, PKBB; PKBBETA; PRKBB; RAC-BETA)

-3.36

2.66

Akt3

V-akt murine thymoma viral oncogene homolog 3(AKT3)

-1.06

1.58

APAF1

Apoptotic peptidase activating factor 1 (APAF-1; CED4)

-4.10

1.09

API5

Apoptosis inhibitor 5 (AAC-11; AAC11)

-5.41

1.06

Bcl-2

B-cell lymphoma 2 (BCL-2)

-1.07

-1.43

BIRC2

Baculoviral IAP repeat-containing 2

1.56

1.23

BIRC3

Baculoviral IAP repeat-containing 3 (AIP1; API2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49; c-IAP2)

-1.84

3.19

Caspase-3

Apoptosis-related cysteine peptidase 3(Casp3)

1.91

2.38

Caspase-4

Apoptosis-related cysteine peptidase 4(Casp4)

-1.31

1.15

Caspase-7

Apoptosis-related cysteine peptidase 7(Casp7)

-2.15

2.03

Caspase-8

Apoptosis-related cysteine peptidase 8(Casp8)

1.87

2.17

Caspase-9

Apoptosis-related cysteine peptidase 9(Casp9)

-4.98

-1.02

Caspase-10

Apoptosis-related cysteine peptidase 10(Casp10)

1.25

2.16

Caspase-12

Apoptosis-related cysteine peptidase 12 (Casp12)

1.24

1.10

CD5

CD5 molecule

-2.41

4.77

CD70

CD70 molecule

1.55

4.04

CD40L

CD40 ligand

-2.51

5.44

CD24

CD24 molecule

1.53

2.98

CD27

CD27 molecule

-2.37

1.71

c-Fos

c-fos proto-oncogene

2.34

3.23

c-Jun

c-Jun proto-oncogene

1.69

5.52

CIDEA

Cell death-inducing DFFA-like effector a

-1.32

-1.58

CIDEB

Cell death-inducing DFFA-like effector b

-2.67

2.98

DAPK1

Death-associated protein kinase 1

-2.80

1.24

DAPK2

Death-associated protein kinase 2

-1.81

1.32

DAPK3

Death-associated protein kinase 3 (ZIP; ZIPK)

-10.17

2.06

DFFA

DNA fragmentation factor subunit alpha (DFF-45; DFF1; ICAD)

-2.09

-1.14

E2F1

Transcription factor E2F1 (RBAP1; RBBP3; RBP3)

-3.99

-1.17

E2F2

Transcription factor E2F2

-1.64

1.55

EGFR

Epidermal growth factor receptor

-4.78

1.38

ENDOG

Endonuclease G

-11.37

1.06

ERBB3

Receptor tyrosine-protein kinase erbB-3 (ErbB-3; HER3; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3)

-2.29

1.54

FADD

Fas-associated protein with death domain (MORT1)

-1.48

-1.42

FasL

Fas ligand (FAS L, CD95L; CD178; TNFSF6)

-1.14

7.53

Fas

Fas receptor (ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6)

-1.23

3.26

IFN-α2

Interferon alpha-2

1.13

1.54

IFN-β1

Interferon beta

5.22

1.47

IGF1

Insulin-like growth factor 1 (IGF-I; IGF1A; IGFI)

-1.14

-1.15

IGF1 R

Insulin-like Growth Factor 1 (IGF-1), Receptor (CD221; IGFIR; IGFR; JTK13)

-3.50

1.27

IKBKB

inhibitor of nuclear factor kappa-B kinase subunit beta (IKK-beta; IKK2; IKKB; NF-κBIKB)

-3.52

1.33

IKBKG

inhibitor of nuclear factor kappa-B kinase subunit gamma (AMCBX1; FIP3; IKK-gamma; IP1; IP2; IPD2; NEMO)

-5.76

1.40

IL-10

Interleukin 10

1.10

12.15

IL-1α

Interleukin-1 alpha

-2.60

1.64

IL-1β

Interleukin-1 beta

-2.20

1.30

IL-2

Interleukin 2

1.24

12.15

IL-4

Interleukin 4

-3.72

2.39

IL-6R

Interleukin 6 receptor (CD126)

-5.80

1.92

IL-7

Interleukin 7

-1.65

1.26

IRAK1

Interleukin-1 receptor-associated kinase 1

-3.70

3.39

JAK2

Janus kinase 2 (JTK10; THCYT3)

1.06

-1.21

MAP3K1

Mitogen-activated protein kinase kinase kinase 1 (MAPKKK1; MEKK; MEKK 1; MEKK1; SRXY6)

-4.55

1.51

MAP3K5

Mitogen-activated protein kinase kinase kinase 5 (ASK1; MAPKKK5; MEKK5)

-2.39

1.99

MAP2K4

Mitogen-activated protein kinase kinase 4 (JNKK1; MAPKK4; MEK4)

-1.06

2.54

MAP2K7

Mitogen-activated protein kinase kinase 7(MAPKK7; MEK7)

-1.09

3.05

MAPK1

Mitogen-activated protein kinase 1 (ERK; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41)

-2.21

1.00

MAPK3

Mitogen-activated protein kinase 3(ERK1; HS44KDAP; P44ERK1; P44MAPK; PRKM3; p44-ERK1; p44-MAPK)

-2.74

1.67

MAPK8

Mitogen-activated protein kinase 8(JNK; JNK1; SAPK1)

1.73

2.53

MAPK9

Mitogen-activated protein kinase 9(JNK2; JNK2A; JNK2B; SAPK)

1.02

2.25

MYD88

Myeloid differentiation primary response gene (88)

-6.09

1.82

NF-κB1

Nuclear factor NF-kappa-B p105 subunit(NFKB-p105; NFKB-p50; NFkappaB; p105; p50)

-4.81

1.18

NF-κB3

Transcription factor p65 (RELA; NF-κB p65)

-1.35

2.63

NF-κBIA

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IKBA; MAD-3; NFKBI)

1.49

2.96

NTRK1

Neurotrophic tyrosine kinase receptor type 1(MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA)

-2.84

1.33

PDCD1

Programmed cell death protein 1( CD279; PD-1; hPD-l)

-1.63

4.48

PDCD4

Programmed cell death protein 4

-1.30

1.06

PDCD 7

Programmed cell death protein 7

1.87

1.42

PI3K-α

Phosphoinositide-3-kinase, catalytic, alpha polypeptide(PIK3CA; p110-alpha; PI3K)

-1.26

1.04

PI3K-γ

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG ; PI3K; PI3Kgamma; PIK3)

-1.40

5.18

PIK3R2

Phosphatidylinositol 3-kinase regulatory subunit beta(P85B; p85; p85-BETA)

-2.12

-1.20

PPP3R1

protein phosphatase 2B regulatory subunit 1(CALNB1; CNB; CNB1)

-1.52

1.94

RIPK1

Receptor-interacting serine/threonine-protein kinase 1(RIP; RIP1)

-2.44

1.24

STAT1

Signal transducers and activators of transcription (CANDF7; ISGF-3; STAT91)

-6.18

4.04

STAT5A

Signal transducer and activator of transcription 5A

-1.14

-1.15

STAT5B

Signal transducer and activator of transcription 5B

-3.17

1.08

TGFB1

Transforming growth factor beta 1(CED; DPD1; LAP; TGFB; TGFbeta)

-2.23

-1.15

TNF-α

Tumor necrosis factors

-1.97

2.19

TNFRSF10A

Tumor necrosis factor receptor superfamily member 10A (APO2; CD261; DR4; TRAILR-1; TRAILR1)

-2.82

2.03

TNFRSF10B

Tumor necrosis factor receptor superfamily member 10B (DR5, CD262, TRICK2, TRICKB, TRAILR2, TRICK2A, TRICK2B)

-2.84

1.02

P53

Tumor protein 53(LFS1; TP53; TRP53)

-7.60

1.32

XIAP

X-linked inhibitor of apoptosis protein(API3; BIRC4; IAP-3; ILP1; MIHA; XLP2; hIAP3)

-1.94

2.59

  1. Negative values indicate down-regulation of genes.