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Table 4 Distribution of PfCRT polymorphism according to the drug sensitivities

From: In vitroantimalarial susceptibility and molecular markers of drug resistance in Franceville, Gabon

Drug Profils N N° (%), of strains with polymorphism : (Pfcrt)
HAPLOTYPE 72-76
CVIEK CVIET MIX p
CQ Resistant (IC50 ≥ 100 nM) 20 0 (0.0%) 20 (100.0%) 0 (0.0%) 0.56
Sensitive (IC50 < 100 nM) 26 1 (3.8%) 25 (96.2%) 0 (0.0%)
MDAQ Resistant (IC50 ≥ 60 nM) 24 1 (4.2%) 23 (95.8%) 0 (0.0%) 0.29
Sensitive (IC50 < 60 nM) 22 0 (0.0%) 22 (100%) 0 (0.0%)
MF Resistant (IC50 ≥ 20 nM) 11 0 (0.0%) 11 (100.0%) 0 (0.0%) 0.58
Sensitive (IC50 < 20 nM) 35 1 (2.9%) 34 (97.1%) 0 (0.0%)
DHA Reduced susceptibility (IC50 ≥ 10 nM) 11 1 (9.1%) 10 (90.9%) 0 (0.0%) 0.23
  Sensitive (IC50 < 10 nM) 35 0 (0.0%) 35 (100.0%) 0 (0.0%)