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Table 3 Distribution of PfMDR1 polymorphism according the status drug sensitivity groups

From: In vitroantimalarial susceptibility and molecular markers of drug resistance in Franceville, Gabon

Drug

Profils

N

N° (%), of strains with polymorphism : (Pfmdr)

N86Y

D1246Y

N

Y

MIX

p

D

Y

MIX

p

CQ

Resistant (IC50>100 nM)

20

13 (65.0%)

6 (30.0%)

1 (5.0%)

0.39

14 (70.0%)

2 (10.0%)

4 (20.0%)

0.3

Sensitive (IC50<100 nM)

26

15 (57.7%)

11 (42.3%)

0 (0.0%)

 

18 (69.2%)

6 (23.1%)

2 (7.7%)

MDAQ

Resistant (IC50 ≥ 60 nM)

24

14 (58.3%)

9 (37.5%)

1 (4.2%)

0.28

16 (66.7%)

3 (12.5%)

5 (20.8%)

0.09

Sensitive (IC50 < 60 nM)

22

12 (54.5%)

10 (45.5%)

0 (0.0%)

 

20 (90.9%)

0 (0.0%)

2 (9.1%)

MF

Resistant (IC50>20 nM)

11

6 (54.5%)

5 (45.5%)

0 (0.0%)

0.7

7 (63.6%)

2 (18.2%)

2 (18.2%)

0.23

Sensitive (IC50<20 nM)

35

22 (62.8%)

12 (34.3%)

1 (2,9%)

 

28 (80.0%)

2 (5.7%)

5 (14.3%)

DHA

Reduced susceptibility (IC50 ≥ 10 nM)

11

6 (54.5%)

5 (45.5%)

0 (0.0%)

0.7

9 (81.8%)

1 (9.1%)

1 (9.1%)

0.53

Sensitive (IC50<10 nM)

35

22 (62.8%)

12 (34.3%)

1 (2.9%)

 

27 (77.1%)

2 (5.7%)

6 (17.1%)