|
Characteristic
|
Non-invasive ventilation
|
|---|
| |
With successful outcomes‡ (n = 38)
|
With failure outcomes (n = 45)
|
Pvalue
|
ORuadj (95% CI)
|
ORadj (95% CI)
|
|---|
|
Age (Mean ± SD, years)
|
26.1 ± 4.3
|
25.5 ± 4.3
|
0.61
|
0.97 (0.88-1.08)
| |
|
BMI, median (IQR)
|
25.2 (24.4-28.8)
|
27.0 (24.5-30.4)
|
0.31
|
1.08 (0.93-1.25)
|
1.06 (0.72-1.56)
|
|
Gestational age, median (IQR)
|
32 (26-35)
|
32 (28-36)
|
0.96
|
0.99 (0.93-1.07)
|
0.97 (0.82-1.15)
|
|
Respiratory diseases (%)
|
2/37 (5.4)
|
1/44 (2.3)
|
0.48
|
0.42 (0.04-4.79)
| |
|
Pneumonia (%)
|
37/38 (97.4)
|
43/45 (95.6)
|
0.65
|
1.76 (0.15-20.23)
| |
|
Symptoms and Lab findings
| | | | | |
|
T ≥ 38°C(%)
|
33/37 (89.2)
|
39/42 (92.9)
|
0.86
|
1.57 (0.33-7.56)
| |
|
Dyspnoea (%)
|
24/38 (63.2)
|
31/44 (70.5)
|
0.43
|
0.68 (0.26-1.76)
| |
|
Hemoptysis (%)
|
6/38 (15.8)
|
9/43 (20.9)
|
0.62
|
1.34 (0.42-4.23)
| |
|
CNS symptom ※ (%)
|
1/38 (2.6)
|
9/44 (20.5)
|
0.04
|
9.51 (1.15-79.03)
|
1.48 (0.96-13.45)
|
|
WBC (×109/L), (Mean ± SD)
|
7.2 ± 3.6
|
7.6 ± 3.9
|
0.63
|
1.03 (0.91-1.16)
| |
|
Hb (g/L) (Mean ± SD)
|
105.9 ± 15.6
|
99.0 ± 15.7
|
0.06
|
0.97 (0.94-1.02)
| |
|
PLT (×109/L) (Mean ± SD)
|
155.5 ± 44.1
|
151.7 ± 56.7
|
0.75
|
1.00 (0.99-1.01)
| |
|
ALT (U/L) (Mean ± SD)
|
43.3 ± 60.9
|
48.9 ± 61.2
|
0.69
|
1.002 (0.99-1.01)
| |
|
CRP (mg/L) (Mean ± SD)
|
71.2 ± 52.9
|
90.8 ± 56.6
|
0.36
|
1.01 (0.99-1.02)
| |
|
PaO2/FiO2
| | | | | |
|
PaO2/FiO2 ≥ 300 (%)
|
7/24 (29.2)
|
3/33 (9.1)
| |
Referent
| |
|
PaO2/FiO2 201 to 300 (%)
|
3/24 (12.5)
|
4/33 (12.1)
|
0.27
|
3.11 (0.41-23.93)
| |
|
PaO2/FiO2 ≤ 200 (%)
|
14/24 (58.3)
|
26/33 (78.8)
|
0.06
|
4.33 (0.97-23.83)
| |
|
APACHE II score, median (IQR)
|
7 (7-11)
|
10 (6-14)
|
0.01
|
1.14 (1.02-1.27)
|
1.20 (0.97-1.49)
|
|
Septic shock (%)
|
1/24 (4.2)
|
17/32 (53.1)
|
0.002
|
27.93 (3.34-33.47)
|
32.87 (1.91-566.52)
|
|
Acute liver damage **(%)
|
4/25 (16.0)
|
12/28 (42.9)
|
0.04
|
3.93 (1.07-14.52)
|
5.17 (0.47-56.37)
|
|
Pleural effusion (%)
|
11/35 (31.4)
|
12/40 (30.0)
|
0.89
|
1.07 (0.40-2.86)
| |
- ORuadj, unadjusted odds ratio; ORadj, Adjusted odds ratio; CI, confidence Interval; BMI, body mass index; IQR, interquartile range; APACHE II, acute physiology and chronic health evaluation II; ICU, intensive care unit
- * Date are presented as no./total no., if otherwise stated. Percentages are based on women with complete information in the respective categories
- ‡ included 38 patients survived after receiving NIV
- ¶ included 7 patients died of respiratory failure who received NIV, 38 patients who received NIV firstly, then changed to invasive ventilation
- ※ CNS system symptoms: refers to one or more of the following symptoms: insomnia, restlessness, hallucination, headache, dizziness and abnormal behaviour.
- ** Acute liver damage: AST or ALT > 70 U/L, or Tbil > 2 mg/dL.
- Variables included in multivariate model: BMI, Gestational age, CNS symptom, APACHE II score, septic shock, acute liver damage
