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Table 1 Characterization of MRSA from Nigeria by antibiotic resistance pattern, detection of genes and molecular typing

From: Characterization of methicillin-susceptible and -resistant staphylococci in the clinical setting: a multicentre study in Nigeria

Isolate No

Location

Sample Or Clinical Diagnosis

Antibiogram

tuf gene

mecA gene

dfrA gene

SCCmec typing

PVL gene

spa type

MLST (ST)

Clonal Complex (CC)

50

Lagos1

Burns

PEN, OXA, GEN, CIP, MOX, ERY, CLI*, TET, COT, RIF

+

+

+

III

-

t037

ST241

CC8

2496ψ

Maiduguri

GTI

PEN, OXA, GEN, CIP, ERY, CLI, TET, COT

+

+

-

NT/UNT

-

t037**

2589

Maiduguri

GTI

PEN, OXA, GEN, CIP, ERY, CLI, TET, COT

+

+

-

NT

-

t037

60ψ

Lagos1

ASOM

PEN, OXA, TET, COT

+

+

-

NT/V

-

t064**

ST8

CC8

69¶

Lagos1

Nasal swab/Screening

PEN, OXA, GEN, TET, COT

+

+

-

NT

-

t064

T39sB

Iwo

HIV/AIDS

PEN, OXA, TET, COT

+

+

-

NT

-

t064

T6530

Ile-Ife

Osteomyelitis

PEN, OXA, GEN, CIP, TET, COT

+

+

-

IV

-

t064

TU32

Ibadan

Wound Infection

PEN, OXA, CIP, TET, COT

+

+

-

NT

-

t064

TU3ψ

Ibadan

Wound Infection

PEN, OXA, CIP, TET, COT

+

+

-

NT/V

-

t064

T5056

Ile-Ife

Bronchitis

PEN, OXA, GEN, CIP, ERY, CLI*, TET, COT, FUS, RIF

+

+

-

III

-

t074

ST37

CC30

TD17

Ile-Ife

Bronchitis

PEN, OXA, ERY, CLI

+

+

ND

II

-

t007

ST39

TN45

Ile-Ife

Wound Infection

PEN, OXA, TET

+

+

ND

IV

-

t729

ST88

CC88

003B

Maiduguri

Septicaemia

PEN, OXA, TET, COT

+

+

+

IV

-

t1603

008

Maiduguri

Septicaemia

PEN, OXA, COT

+

+

+

IV

-

t1603

T5843ψ

Ile-Ife

Osteomyelitis

PEN, OXA, TET, COT

+

+

-

NT/UNT

+

t4690**

ST152

singleton

  1. KEY:
  2. ψ: Representative MRSA for SCCmec typing determined by Kondo et al. (2007).
  3. ¶Nasal samples of health care workers (HCWs) in one of the hospitals in Lagos (designated as Lagos1).
  4. Geographical region (Nigeria): South-West (Ile-Ife, Ibadan, Iwo and Lagos); North-East (Maiduguri); North Central (Jos).
  5. GTI: Genital Tract Infection; ASOM: Acute suppurative otitis media.
  6. Antibiotics - PEN: Penicillin; OXA: Oxacillin; GEN: Gentamicin; CIP: Ciprofloxacin; MOX: Moxifloxacin; ERY: Erythromycin; CLI: Clindamycin; TET: Tetracycline; FUS: Fusidic acid; RIF: Rifampicin; COT: Cotrimoxazole; *: Inducible resistance (clindamycin).
  7. UNT: Untypeable SCCmec types; NT: Non-typeable; ND: Not determined.
  8. Isolates with spa type t007, t074, t729 and t1603 were assigned STs based on the Based Upon Repeat Pattern (BURP) via the Ridom StaphType software.
  9. **: MLST on representative strains.