Strain | Time point | Group | Na | Seroconversion rate | Seroprotection rate | Geometric mean fold rise >2.5 | Geometric mean titre |
---|---|---|---|---|---|---|---|
Value or % [95% CIa] | |||||||
A/Brisbane/59/2007 | Day 21 | A | 92 | 77.2% [67.2-85.3%] | 93.5% [86.3-97.6%] | 8.4 [6.5-10.8] | 145.1 [115.9-181.6] |
B | 86 | 86.0% [76.9-92.6%] | 97.7% [91.9-99.7%] | 12.9 [10.0-16.6] | 215.7 [168.2-276.5] | ||
C | 92 | 82.6% [73.3-89.7%] | 96.7% [90.8-99.3%] | 12.0 [9.4-15.4] | 226.3 [181.4-282.2] | ||
D | 88 | 79.5% [69.6-87.4%] | 92.1% [84.5-96.8%] | 9.6 [7.7-12.1] | 158.7 [127.9-197.1] | ||
Day 42 | E | 91 | 18.7% [11.3-28.2%] | 51.6% [40.9-62.3%] | 2.3 [1.9-2.6] | 32.9 [27.3-39.7] | |
F | 91 | 30.8% [21.5-41.3] | 68.1% [57.5-77.5%] | 3.2 [2.7-3.8] | 53.2 [43.5-65.1] | ||
Day 63 | A | 92 | 68.5% [58.0-77.8%] | 91.3% [83.6-96.2%] | 6.9 [5.4-8.9] | 120.2 [96.5-149.7] | |
B | 86 | 88.4% [79.7-94.3%] | 100% [95.8-100%] | 11.2 [9.1-13.7] | 186.5 [150.4-231.4] | ||
C | 92 | 75.0% [64.9-83.4%] | 92.4% [84.9-96.9%] | 8.4 [6.6-10.6] | 157.0 [126.0-195.8] | ||
D | 88 | 72.7% [62.2-81.7%] | 88.8%[80.3-94.5%] | 7.6 [6.0-9.5] | 124.3 [99.0-156.1] | ||
E | 91 | 78.0% [68.1-86.0%] | 89.0% [80.7-94.6%] | 9.4 [7.6-11.7] | 137.4 [109.0-173.1] | ||
F | 91 | 83.5% [74.3-90.5%] | 95.6% [89.1-98.8%] | 10.1 [8.1-12.6] | 166.9 [132.5-210.3] | ||
Day 182 | A | 92 | 48.9% [38.3-59.6%] | 68.5% [58.0-77.8%] | 4.0 [3.1-5.3] | 68.5 [53.6-87.4] | |
B | 89 | 64.0% [53.2-73.9%] | 83.1% [73.7-90.2%] | 5.2 [4.2-6.6] | 89.2 [71.0-112.0] | ||
C | 85 | 52.9% [41.8-63.9%] | 77.6% [67.3-86.0%] | 4.7 [3.7-6.0] | 87.4 [68.5-111.5] | ||
D | 89 | 43.2% [32.7-54.2%] | 68.5% [57.8-78.0%] | 3.7 [2.9-4.8] | 64.6 [51.4-81.1] | ||
E | 89 | 51.7% [40.8-62.4%] | 75.3% [65.0-83.8%] | 4.4 [3.5-5.4] | 64.6 [51.4-81.1] | ||
F | 91 | 59.3% [48.5-69.5%] | 78.0% [68.1-86.0%] | 5.0 [4.0-6.3] | 83.7 [66.0-106.2] | ||
A/Uruguay/716/2007 | Day 21 | A | 92 | 78.3% [68.4-86.2%] | 84.8% [75.8-91.4%] | 17.4 [13.0-23.3] | 175.7 [129.6-238.2] |
B | 86 | 84.9% [75.5-91.7%] | 89.5% [81.1-95.1%] | 15.5 [11.8-20.4] | 183.5 [135.2-248.9] | ||
C | 92 | 78.3% [68.4-86.2%] | 83.7% [74.5-90.6%] | 20.6 [14.8-28.6] | 181.7 [128.1-257.9] | ||
D | 88 | 86.4% [77.4-92.8%] | 88.8% [80.3-94.5%] | 19.3 [14.2-26.4] | 191.4 [138.4-264.7] | ||
Day 42 | E | 91 | 3.3% [0.7-9.3%] | 19.8% [12.2-29.4%] | 1.2 [1.1-1.4] | 12.5 [10.0-15.6] | |
F | 91 | 6.6% [2.5-13.8%] | 30.8% [21.5-41.3%] | 1.7 [1.5-1.9] | 19.1 [15.6-23.4] | ||
Day 63 | A | 92 | 77.2% [67.2-85.3%] | 84.8% [75.8-91.4%] | 13.3 [10.0-17.6] | 134.4 [100.4-179.9] | |
B | 86 | 80.2% [70.2-88.0%] | 87.2% [78.3-93.4%] | 11.7 [9.1-15.0] | 138.4 [104.8-182.7] | ||
C | 92 | 75.0% [64.9-83.4%] | 79.3% [69.6-87.1%] | 15.0 [11.2-19.9] | 132.0 [94.9-183.7] | ||
D | 88 | 78.4% [68.4-86.5%] | 84.3% [75.0-91.1%] | 14.6 [10.9-19.6] | 145.6 [107.7-196.8] | ||
E | 91 | 82.4% [73.0-89.6%] | 89.0% [80.7-94.6%] | 20.8 [15.5-28.0 | 216.1 [160.0-292.0] | ||
F | 91 | 85.7% [76.8-92.2%] | 91.2% [83.4-96.1%] | 19.3 [14.6-25.5] | 221.9 [167.2-294.6] | ||
Day 182 | A | 92 | 63.0% [52.3-72.9%] | 71.7% [61.4-80.6%] | 9.0 [6.7-11.9] | 89.5 [65.8-121.8] | |
B | 89 | 62.9% [52.0-72.9%] | 71.9% [61.4-80.9%] | 7.2 [5.6-9.3] | 87.7 [64.0-120.3] | ||
C | 85 | 63.5% [52.4-73.7%] | 70.6% [59.7-80.0%] | 9.7 [7.2-13.1] | 87.1 [61.4-123.5] | ||
D | 89 | 63.6% [52.7-73.6% | 71.9% [61.4-80.9%] | 8.5 [6.2-11.7] | 87.8 [63.4-121.4] | ||
E | 89 | 67.4% [56.7-77.0%] | 76.45 [66.2-84.85] | 9.9 [7.3-13.5] | 110.0 [79.3-152.6] | ||
F | 91 | 67.0% [56.4-76.5%] | 76.9% [66.9-85.1%] | 10.6 [7.9-14.2] | 127.2 [92.3-175.5] | ||
B/Brisbane/60/2008 | Day 21 | A | 92 | 82.6% [73.3-89.7%] | 98.9% [94.1-100%] | 12.6 [9.8-16.2] | 662.1 [545.4-803.8] |
B | 86 | 88.4% [79.7-94.3%] | 98.8% [93.7-100%] | 13.9 [11.1-17.5] | 658.3 [540.2-802.0] | ||
C | 92 | 80.4% [70.9-88.0%] | 97.8% [92.4-99.7%] | 10.5 [8.3-13.5] | 478.8 [389.5-588.6] | ||
D | 88 | 88.6% [80.1-94.4%] | 100% [95.9-100%] | 14.3 [11.0-18.7] | 576.1 [479.8-691.8] | ||
Day 42 | E | 91 | 6.6% [2.5-13.8%] | 82.4% [73.0-89.65] | 1.3 [1.1-1.5] | 74.7 [61.4-90.9] | |
F | 91 | 26.4% [17.7-36.7%] | 97.8% [92.3-99.7%] | 2.4 [2.0-2.8] | 139.5 [120.0-162.2] | ||
Day 63 | A | 92 | 79.3% [69.6-87.1%] | 98.9% [94.1-100%] | 9.6 [7.5-12.4] | 506.7 [422.3-608.0] | |
B | 86 | 84.9% [75.5-91.7%] | 100% [95.8-100%] | 10.0 [8.1-12.2] | 471.2 [396.3-560.2] | ||
C | 92 | 72.8% [62.6-81.6%] | 98.9% [94.1-100%] | 7.9 [6.3-9.9] | 359.6 [299.4-431.9] | ||
D | 88 | 83.0% [73.4-90.1%] | 100% [95.9-100%] | 10.8 [8.4-13.7] | 433.5 [369.5-508.7] | ||
E | 91 | 85.7% [76.8-92.2%] | 100% [96.0-100%] | 11.4 [9.1-14.2] | 644.9 [534.5-778.2] | ||
F | 91 | 83.5% [74.3-90.5%] | 100% [96.0-100%] | 11.9 [9.4-15.0] | 688.1 [593.0-798.6] | ||
Day 182 | A | 92 | 73.9% [63.7- 82.5%] | 97.8% [92.4-99.7%] | 6.7 [5.2-8.6] | 339.9 [276.7-417.5] | |
B | 89 | 60.7% [49.7-70.9%] | 98.9% [93.9-100%] | 5.7 [4.5-7.1] | 273.8 [228.7-327.9] | ||
C | 85 | 56.5% [45.3-67.2%] | 92.9% [85.3-97.4%] | 5.5 [4.3-6.9] | 245.4 [197.8-304.3] | ||
D | 89 | 72.7% [62.2-81.7%] | 100% [95.9-100%] | 6.8 [5.3-8.6] | 292.6 [247.0-346.7] | ||
E | 89 | 75.3% [65.0-83.8%] | 98.9% [93.9-100%] | 6.9 [5.4-8.7] | 369.6 [300.0-455.3] | ||
F | 91 | 68.1% [57.5-77.5%] | 100% [96.0-100%] | 6.4 [5.0-8.1] | 378.4 [323.4-442.8] |