| |
Incidence ofmedical death
|
Estimated excess mortality per 1000 person-years (95% CI)
|
P-value
|
Number needed to treat per year (95% CI) to avert 1 death
|
|---|
|
HIV-1 uninfected
|
3.6
|
Reference
|
-
|
Reference
|
|
HIV-1 infected
|
13.7
|
10.2 (6.9, 13.5)
|
<.001
| |
|
CD4 cell count
| | | | |
|
≥500
|
4.8
|
1.2 (−1.8, 4.2)
|
.44
|
851
|
|
350-499
|
13.1
|
8.9 (3.8, 14.0)
|
<.001
|
113
|
|
250-349
|
19.9
|
15.2 (8.1, 22.2)
|
<.001
|
66
|
|
<250
|
42.7
|
29.3 (13.9, 44.7)
|
<.001
|
34
|
|
HIV-1 RNA
| | | | |
|
HIV-1 <10 K
|
7.7
|
2.0 (−1.1, 5.0)
|
.21
|
509
|
|
10 K-50 K
|
3.7
|
−0.6 (−3.4, 2.3)
|
.69
|
NA
|
|
50 K-100 K
|
13.9
|
6.7 (−0.6, 14.0)
|
.071
|
149
|
|
>100 K
|
46.9
|
43.0† (29.6, 56.4)
|
<.001
|
23
|
- † An interaction term was also present in the model between high HIV viral load and use of ART (p = .002). The excess mortality in the last row applies to those not on ART. For those on ART, mortality was not found to exceed that of HIV-1 uninfected (p = 0.58).
