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Table 2 Clinical and laboratory adverse events of antifungal prophylaxis

From: Analysis of posaconazole as oral antifungal prophylaxis in pediatric patients under 12 years of age following allogeneic stem cell transplantation

Variable No. (%) (n = 60)
Drug related adverse events  
 Clinical (total) 5 (8.3)
 Fever 0 (0)
 Pruritus 1 (1.7)
 Nausea 3 (5.0)
 Vomiting 1 (1.7)
Increase in alanine aminotransferase  
 ≥ 2.0 x normal value 39 U/L 10 (16.7)
 ≥ 3.0 x normal value 39 U/L 9 (15)
Increase in aspartate aminotransferase  
 ≥ 2.0 x normal value 59 U/L 1 (1.7)
 ≥ 3.0 x normal value 59 U/L 0 (0)
Increase in total bilirubin  
 ≥ 2.0 x normal value 1.1 mg/dl 0 (0)
 ≥ 3.0 x normal value 1.1 mg/dl 0 (0)
Increase in direct bilirubin  
 ≥ 2.0 x normal value 0.3 mg/dl 2 (3.4)
 ≥ 3.0 x normal value 0.3 mg/dl 0 (0)
Analysis of cyclosporin A level (n = 28)
 ≥ 1.5 x baseline day 2-3 8 (28.6)
 ≥ 2.0 x baseline day 2-3 2 (7.1)
 ≥ 1.5 x baseline day 4-6 9 (32.1)
 ≥ 2.0 x baseline day 4-6 1 (3.6)
 ≥ 1.5 x baseline day 8-12 4 (14.3)
 ≥ 2.0 x baseline day 8-12 1 (3.6)
 ≥1.5 x baseline day 16-20 1 (3.6)
 ≥ 2.0 x baseline day 16-20 0 (0.0)