Posaconazole trough levels. Analysis of posaconazole morning trough levels at 5 mg/kg body weight daily (b.i.d.) (n = 48) and morning trough levels at 4 mg/kg body weight daily (t.i.d.) (n = 41). These morning trough levels were significantly different (P < 0.001) according to the Mann-Whitney U test. The gray area indicates the reported range of posaconazole trough levels in adults.