Hepatotoxicity. Box plot of liver parameters the day before posaconazole therapy began (Before), their maximums during therapy (Maximum), and values at the end of oral antimycotic monoprophylaxis with posaconazole (End). A: Plasma alanine aminotransferase (ALT) (normal value, ≤ 39 U/L). B: Plasma aspartate aminotransferase (AST) (normal value, ≤ 59 U/L for pediatric patients < 12 years of age). C: Total plasma bilirubin (normal value, ≤ 1.1 mg/dL). D: Direct plasma bilirubin (normal value, ≤ 0.3 mg/dL). Statistical analysis by the Wilcoxon matched-pairs signed-ranks test showed a significant increase (***P < 0.001) in ALT and AST beyond their upper normal limits during treatment post-transplant respective to baseline measurements taken the day before the start of posaconazole prophylaxis (Before).