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Table 3 Co-resistance among macrolide-resistant isolates of Streptococcus pneumoniae, 2005-2009

From: Macrolide resistance determinants among Streptococcus pneumoniae isolates from carriers in Central Greece

Antibiotic nonsusceptibility

erm(B)

erm(B)+mef(E)

mef(E)

mef(A)

 

(n=75)

(n=64)

(n=110)

(n=14)

 

CLSI

EUCAST

CLSI

EUCAST

CLSI

EUCAST

CLSI/EUCAST

Penicillin-nonsusceptible

 MIC50/90 (MIC range)

1/2 (0.125-2)

2/4 (0.25-4)

0.25/2 (0.125-4)

 

  Intermediate

43 (57.3)a,b

58 (77.3)c

21 (32.8)

52 (81.2)

85 (77.3)

105 (95.5)

0

  Resistant

15 (20)

0

43 (67.2)

12 (18.8)

22 (20)

2 (1.8)

0

Clindamycin

75 (100)

75 (100)

64 (100)

64 (100)

0

0

0

Tetracycline

55 (73.3)

55 (73.3)

63 (98.4)

63 (98.4)

40 (36.4)

40 (36.4)

0

Chloramphenicol

41 (54.7)

41 (54.7)

1 (1.6)

1 (1.6)

0

0

0

TMP-SMZ

62 (82.7)

61 (81.3)

64 (100)

64 (100)

48 (43.6)

45 (40.9)

0

MDR

74 (98.7)

73 (97.3)

64 (100)

64 (100)

48 (43.6)

46 (41.8)

0

  1. aNumber in parentheses is percent, unless otherwise indicated.
  2. bOral penicillin V breakpoints.
  3. cBenzylpenicillin breakpoints (infections other than meningitis).
  4. TMP-SMZ: trimethoprim-sulfamethoxazole; MDR: multidrug-resistant.