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Table 3 Distribution of cervical abnormalities at the end of follow-up&by age and hrHPV status at entry among 493 women with ASC-US from 5 sentinel screening centres in Catalonia (Spain)

From: Prediction of cervical intraepithelial neoplasia grade 2+ (CIN2+) using HPV DNA testing after a diagnosis of atypical squamous cell of undetermined significance (ASC-US) in Catalonia, Spain

 

AGE

DIAGNOSIS AT LAST FOLLOW UP&

BY hrHPV STATUS

< 25 N

(%)

25-34

N (%)

35-44

N (%)

45-54

N (%)

> 54

N (%)

Total

N (% HPV positive)*

84(17) 61(72.6)

182(36.9) 101(55.5)

100(20,3) 38(38.0)

108(21.9) 32(29.6)

19(3.9) 6(31.6)

hrHPV Positive

N (%) within diagnostic category

Cancer (N = 2)

0

0

0

1(50.0)

1(50.0)

CIN3/HSIL (N = 17)

3(17.6)

7(41.1)

4(23.5)

3(17.6)

0(0)

CIN2 (N = 17)

5(29.4)

8(47.0)

2(11.8)

1(5.9)

1(5.9)

Other milder diagnosis (N = 94)

19(20.2)

46(48.9)

19(20.2)

9(9.6)

1(1.1)

Normal (N = 108)

34(31.5)

40(37.0)

13(12.0)

18(16.7)

3(2.8)

Total (N = 238)

61(25.6)

101(42.4)

38(15.9)

32(13.4)

6(2.5)

hrHPV Negative

N (%) within diagnostic category

CIN 2+ (N = 1)

0

0

1 (100)

0

0

Other milder diagnosis (N = 35)

7(20.0)

10(28.6)

9(25.7)

9(25.7)

0

Normal (N = 220)

16(7.2)

71(32.3)

53(24.1)

67(30.4)

13(5.9)

Total (N = 255)

23(9.0)

81(31.8)

62(24.3)

76(29.8)

13(5.1)

  1. &Maximum follow up period 3.5 years
  2. P value for linear trend < 0.0
  3. CIN2: high grade cervical intraepithelial lesions grade 2, CIN3: high grade cervical intraepithelial lesions grade 3, HSIL: High grade squamous intraepithelial lesion