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Table 3 Risk factors for 30-day mortality among patients with community-onset Klebsiella pneumoniae bloodstream infection in univariate analysis

From: Differences in characteristics between healthcare-associated and community-acquired infection in community-onset Klebsiella pneumoniae bloodstream infection in Korea

  No. of survivors No. of non-survivors OR (95% CI) p
(n = 456) (n = 97)
Age (year) (mean ±SD) 61.1 (±13.5) 63.3 (±12.1)   0.146
Male sex 287 (62.9) 61 (62.9) 1.00 (0.63-1.57) 0.992
Underlying disease     
  Diabetes mellitus 128 (28.1) 17 (17.5) 0.55 (0.31-0.96) 0.032
  Chronic liver disease 94 (20.6) 29 (29.9) 1.64 (1.01-2.68) 0.046
  Biliary tract disease 77 (16.9) 8 (8.2) 0.44 (0.21-0.95) 0.032
  Chronic kidney disease 28 (6.1) 4 (4.1) 0.66 (0.26-1.92) 0.440
  Respiratory disease 34 (7.5) 5 (5.2) 0.68 (0.26-1.77) 0.421
  Solid tumor 173 (37.9) 65 (67.0) 3.32 (2.09-5.28) <0.001
  Hematologic malignancy 16 (3.5) 11 (11.3) 3.52 (1.58-7.84) 0.003
  Solid organ transplantation 13 (2.9) 1 (1.0) 0.36 (0.05-2.75) 0.482
Charlson's WIC (≥3) 135 (29.6) 53 (54.6) 2.86 (1.83-4.48) <0.001
Primary infection site     
  Urinary tract 58 (12.7) 7 (7.2) 0.53 (0.24-1.22) 0.126
  Peritoneum 42 (9.2) 15 (15.5) 1.80 (0.96-3.40) 0.066
  Pancreatobiliary tract 163 (35.7) 21 (21.6) 0.50 (0.30-0.84) 0.007
  Liver 105 (23.0) 3 (3.1) 0.11 (0.03-0.35) <0.001
  Lung 27 (5.9) 17 (17.5) 3.38 (1.76-6.48) <0.001
  Skin and soft tissue 8 (1.8) 4 (4.1) 2.41 (0.71-8.17) 0.239
  Bone 5 (1.1) 1 (1.0) 0.94 (0.11-8.13) 1.000
  Central nervous system 1 (0.2) 0 (0) 0.82 (0.79-0.86) 1.000
  Othersa 3 (0.7) 1 (1.0) 1.57 (0.16-15.28) 0.539
  Unknown 45 (9.9) 28 (28.9) 3.71 (2.17-6.34) <0.001
Metastatic infection 18 (3.9) 2 (2.1) 0.51 (0.12-2.25) 0.551
Endophthalmitis 8 (1.8) 0 (0) 0.82 (0.79-0.86) 0.362
Pitt bacteremia score (≥4) 46 (10.1) 46 (47.4) 8.04 (4.87-13.28) <0.001
Shock at presentation 97 (21.3) 59 (60.8) 5.75 (3.61-9.15) <0.001
Neutropenia at presentation 25 (5.5) 20 (20.6) 4.48 (2.37-8.46) <0.001
Healthcare-associated infection 243 (53.3) 70 (72.2) 2.27 (1.41-3.68) 0.001
Polymicrobial infection 57 (12.5) 24 (24.7) 2.30 (1.34-3.94) 0.002
Antimicrobial resistance     
  non-susceptible to CIP 32 (7.0) 9 (9.3) 1.36 (0.63-2.94) 0.440
  non-susceptible to ESC 29 (6.4) 8 (8.2) 1.32 (0.59-2.99) 0.499
Inappropriate empirical antimicrobial therapy 27 (5.9) 13 (13.4) 2.46 (1.22-4.96) 0.010
Inappropriate definitive antimicrobial therapyb 12/446 (2.7) 2/55 (3.6) 1.37 (0.30-6.26) 0.659
  1. Data indicate no. (%) of patients.
  2. WIC, weighted index of co-morbidity; CIP, ciprofloxacin; ESC, extended-spectrum cephalosporin; OR, odds ratio; CI, confidence interval.
  3. a Others were one appendicitis, one pericarditis and two periodontitis.
  4. b 52 patients were excluded from the analysis (15 patients were transferred to other hospitals and 37 died before the culture results were available).