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Table 1 Clinical characteristics of community-acquired and healthcare-associated infections in patients with community-onset Klebsiella pneumoniae bloodstream infection

From: Differences in characteristics between healthcare-associated and community-acquired infection in community-onset Klebsiella pneumoniae bloodstream infection in Korea

 

CA-KpBSI

HCA-KpBSI

p

(n = 240)

(n = 313)

Age (years) (mean ±SD)

63.0 (±13.6)

60.3 (±12.9)

0.015

Male sex

142 (59.2)

206 (65.8)

0.124

Underlying disease

  Diabetes mellitus

74 (30.8)

71 (22.7)

0.031

  Chronic liver disease

39 (16.3)

84 (26.8)

0.003

  Biliary tract disease

42 (17.5)

43 (13.7)

0.224

  Chronic kidney disease

13 (5.4)

19 (6.1)

0.774

  Respiratory disease

18 (7.5)

21 (6.7)

0.719

  Solid tumor

58 (24.2)

180 (57.5)

<0.001

  Hematologic malignancy

4 (1.7)

23 (7.3)

0.002

  Solid organ transplantation

5 (2.1)

9 (2.9)

0.557

Charlson’s WIC (≥3)

47 (19.6)

141 (45.0)

<0.001

Primary infection site

  Urinary tract

31 (12.9)

34 (10.9)

0.457

  Peritoneum

11 (4.6)

46 (14.7)

<0.001

  Pancreatobiliary tract

82 (34.2)

102 (32.6)

0.696

  Liver

67 (27.9)

41 (13.1)

<0.001

  Lung

16 (6.7)

28 (8.9)

0.326

  Skin and soft tissue

4 (1.7)

8 (2.6)

0.477

  Bone

4 (1.7)

2 (0.6)

0.411

  Central nervous system

1 (0.4)

0 (0)

0.434

  Othersa

1 (0.4)

3 (1.0)

0.637

  Unknown

21 (8.8)

52 (16.6)

0.007

Metastatic infection

11 (4.6)

9 (2.9)

0.286

Endophthalmitis

5 (2.1)

3 (1.0)

0.303

Pitt bacteremia score (≥4)

36 (15.0)

56 (17.9)

0.366

Shock at presentation

55 (22.9)

101 (32.3)

0.015

Neutropenia at presentation

3 (1.3)

42 (13.4)

<0.001

Polymicrobial infection

34 (14.2)

47 (15.0)

0.780

Initial antimicrobial regimen

  Piperacillin-tazobactam

9 (3.8)

30 (9.6)

0.008

  Quinolone

23 (9.6)

18 (5.8)

0.088

  1st generation cephalosporin

2 (0.8)

0 (0)

0.188

  3rd generation cephalosporin

173 (72.1)

186 (59.4)

0.002

  Carbapenem

30 (12.5)

48 (15.3)

0.342

Inappropriate empirical antimicrobial therapy

14 (5.8)

26 (8.3)

0.266

Inappropriate definitive antimicrobial therapyb

7/223 (3.1)

7/278 (2.5)

0.675

30-day mortality

27 (11.3)

70 (22.4)

0.001

  1. Data indicate no. (%) of patients. WIC, weighted index of co-morbidity; CA-KpBSI, community-acquired Klebsiella pneumoniae bloodstream infection; HCA-KpBSI, healthcare-associated Klebsiella pneumoniae bloodstream infection. a Others were one appendicitis, one pericarditis and two periodontitis. b 52 patients were excluded from the analysis (15 patients were transferred to other hospitals and 37 died before the culture results were available).