|
Patient number (%)
|
191(100)
|
42(22)
|
8(4.2)
|
3(1.6)
|
138(72.3)
|
|
Age, yr
|
50.5(19–80)
|
44(22–80)
|
49.5(24–60)
|
42.67(29–70)
|
52.4(19–79)
|
|
Male gender (%)
|
116(60.7)
|
28(66.7)
|
4(50)
|
3(100)
|
81(58.7)
|
|
Symptoms
| | | | | |
|
Fever (%)
|
95(49.7)
|
29(69)
|
3(37)
|
1(33.3)
|
62(44.9)
|
|
Cough (%)
|
97(50.8)
|
22(52.4)
|
4(50)
|
1(33.3)
|
70(50.7)
|
|
Dyspnea (%)
|
75(39.3)
|
15(35.7)
|
4(50)
|
0
|
56(40.6)
|
|
Sputum (%)
|
40(20.9)
|
10(23.8)
|
0
|
0
|
30(21.7)
|
|
Chills (%)
|
17(8.9)
|
1(2.4)
|
2(25)
|
0
|
14(10.1)
|
|
Chest radiograph/CT scan
| | | | | |
|
Infiltrates (%)
|
105(55)
|
24(57.1)
|
6(75)
|
2(66.7)
|
73(52.9)
|
|
Suspicion of fungi lesion (%)
|
53(27.7)
|
17(40.5)
|
4(50)
|
3(100)
|
29(21)
|
|
Stem cell transplantation
| | | | | |
|
Allogen (%)
|
48(25.1)
|
11(26.2)
|
4(100)
|
3(100)
|
30(21.7)
|
|
Autolog (%)
|
12(6.3)
|
6(14.3)
|
0
|
0
|
6(4.3)
|
|
Immunosuppressive therapy
| | | | | |
|
Steroids (%)
|
67(35.1)
|
13(31)
|
2(25)
|
0
|
52(37.7)
|
|
Ciclosporine (%)
|
48(25.1)
|
13(31)
|
4(50)
|
1(33.3)
|
30(21.7)
|
|
Mycophenolate (%)
|
28(14.7)
|
4(9.5)
|
0
|
0
|
24(17.4)
|
|
Azathioprine (%)
|
9(4.7)
|
2(4.8)
|
1(12.5)
|
0
|
6(5.3)
|
|
Sirolimus (%)
|
10(5.2)
|
2(4.8)
|
1(12.5)
|
0
|
7(5.1)
|
|
Tacrolimus (%)
|
8(4.2)
|
0
|
0
|
0
|
8(5.8)
|
|
Antimicrobial therapy at bronchoscopy
| | | | | |
|
Antibacterial (%)
|
163(85.3)
|
39(92.9)
|
8(100)
|
3(100)
|
113(81.3)
|
|
Antiviral (%)
|
66(34.6)
|
13(31)
|
3(37.5)
|
2(66.7)
|
48(34.8)
|
|
Antifungal (%)
|
111(58.1)
|
32(76.2)
|
7(87.5)
|
3(100)
|
69(50)
|
|
Disease
| | | | | |
|
Hematologic disorders (%)
|
129(67.5)
|
33(78.6)
|
8(100)
|
3(100)
|
85(61.6)
|
|
Solid organ transplants (%)
|
26(13.6)
|
4(9.5)
|
0
|
0
|
22(15.9)
|
|
AIDS (%)
|
12(6.3)
|
0
|
0
|
0
|
12((8.7)
|
|
Autoimmune disorders (%)
|
24(12.6)
|
5(11.9)
|
0
|
0
|
19(13.8)
|
|
Microbiology
| | | | | |
|
Aspergillus culture BAL (%)
|
8(4.2)
|
2(4.8)
|
2(25)
|
1(33.3)
|
3(2.2)
|
|
Bacteriology BAL (%)
|
28(14.7)
|
3(7.1)
|
1(12.5)
|
0
|
24(17.4)
|
|
Positive nPCR BAL (%)
|
55(28.8)
|
10(23.8)
|
4(50)
|
0
|
41(29.7)
|
|
Galactamannan in blood, ng/ml
|
0.226(0.1-3)
|
0.171(0.1-0.5)
|
0.488(0.1-1.3)
|
1.1(0.1-3)
|
0.178(0.1-1.3)
|
|
CRP (mg/L)
|
76.4(0–410)
|
84.8(0.9-296)
|
71.8(2.9-240)
|
61.6(6.8-116)
|
74(0–410)
|
|
Leukocytes (x103/L)
|
7.8
|
4.8
|
2.0
|
2.1
|
9.2
|
|
BAL cells (x106/L)
|
313.8
|
183.6
|
159.4
|
678.3
|
351.6
|
|
macrophages (in%)
|
69.1
|
71.0
|
82.4
|
60.5
|
68
|
|
lymphocytes (in%)
|
15.7
|
15.3
|
11.8
|
4.0
|
16.2
|
|
neutrophiles (in%)
|
16.4
|
9.4
|
6.7
|
35.5
|
18.5
|
|
eosinophiles (in%)
|
0.9
|
0.8
|
0.8
|
0.0
|
1
|
