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Table 4 Proteus mirabilis . and Klebsiella spp non-susceptibility rates a for cases with available clinical data

From: Cefditoren: Comparative efficacy with other antimicrobials and risk factors for resistance in clinical isolates causing UTIs in outpatients

Antimicrobial agent

Proteus mirabilis

Klebsiellaspp.

AUCb(n = 31)

Total cases with available clinical information (n = 75)

AUCb(n = 22)

Total cases with available clinical information (n = 45)

Amoxicillin

35.5

33.3

N/A c

N/A c

Amoxicillin/clavulanic acid

6.5

5.3

0

2.2

Cefalothin

12.9

12.0

4.5

4.4

Cefuroxime sodium

0

2.7

0

0

Cefuroxime axetil

3.2

5.3

4.5

2.2

Co-trimoxazole

16.1

16

9.1

11.1

Nalidixic acid

9.7

6.7

0*

8.9

Ciprofloxacin

6.5

2.7

0

4.4

Mecillinam

25.8

21.3

0

0

Nitrofurantoin

N/A c

N/A c

40.9

33.3

Fosfomycin

0

0

0

2.2

Cefotaxime

3.2

3.2

0

0

Ceftazidime

6.5

5.3

0

0

Gentamicin

0

2.7

0

 

Netilimicin

0

0

0

2.2

Amikacin

0

0

4.5

4.4

Piperacillin-tazobactam

0

0

0

0

Ticarcillin-clavulanate

0

0

0

0

Imipenem

0

0

0

0

Cefditoren

3.2

2.7

0

2.2

  1. a CLSI 2011 breakpoints of susceptibility were applied; b Acute Uncomplicated Cystitis, c not applicable, , *P ≤ 0.05.