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Table 3 Differences in the distribution of cagA and vacA genotypes among different races residing within the same country

From: Role of Helicobacter pylori cagA EPIYA motif and vacAgenotypes for the development of gastrointestinal diseases in Southeast Asian countries: a meta-analysis

    

cagAgenotype

vacAgenotype

 

Area/Race (n)

Patient (n)

cagA(n/%)

Western EPIYA-ABC

East-Asian EPIYA-ABD

s1 (n/%)

s1a (n/%)

s1b (n/%)

s1c (n/%)

s2 (n/%)

m1 (n/%)

m2 (n/%)

s1m1 (n/%)

s1m2 (n/%)

s2m1 (n/%)

s2m2 (n/%)

i1 (n/%)

i2 (n/%)

Vietnam

Hanoi (North)

107

103 (96)

1 (2)

51 (98)

107 (100)

NA

NA

NA

1 (1)

60* (58)

44 (42)

60* (58)

44 (42)

0 (0)

0 (0)

50 (94)

3 (6)

 

Ho Chi Minh (South)

118

90 (94)

3 (7)

43 (93)

96 (100)

NA

NA

NA

0 (0)

32 (34)

62 (66)

32 (34)

62 (66)

0 (0)

0 (0)

44 (94)

3 (6)

Thailand

Thai

38

38 (100)

31# (82)

7 (18)

38 (100)

31 (82)

0 (0)

7# (18)

0 (0)

35# (92)

3 (8)

35 (92)

3 (8)

0 (0)

0 (0)

NA

NA

 

Thai-Chinese

40

40 (100)

16 (42)

24 (60)

40 (100)

17 (43)

0 (0)

23 (58)

0 (0)

28 (70)

12 (30)

28 (70)

12 (30)

0 (0)

0 (0)

NA

NA

 

Chinese

20

20 (100)

3 (15)

17 (85)

20 (100)

5 (25)

0 (0)

15 (75)

0 (0)

8 (40)

12 (60)

8 (40)

12 (60)

0 (0)

0 (0)

NA

NA

Malaysia

Chinese

286

141 (95)

29** (13)

186 (87)

149 (100)

NA

NA

NA

0 (0)

82 (55)

67 (45)

82 (55)

67 (45)

0 (0)

0 (0)

90 (100)

0 (0)

 

Indian

144

82 (94)

93 (89)

11 (11)

78 (90)

27 (82)

4 (12)

2 (6)

9 (10)

61 (70)

26 (30)

61 (70)

17 (20)

0 (0)

9 (10)

44 (90)

5 (10)

 

Malay

75

43 (86)

25 (56)

19 (43)

45 (90)

23 (92)

0 (0)

2 (8)

5 (10)

32 (64)

18 (36)

32 (64)

13 (26)

0 (0)

5 (10)

22 (100)

0 (0)

  1. ‘NA’ (not available) indicates a lack of data associating cagA status, EPIYA motif genotype, and vacA s-, m-, and i-region genotypes.
  2. *: p < 0.05 (significant differences between Northern and Southern parts in Vietnam) by use of chi-square test, #: p < 0.05 (significant differences among Thai, Thai-Chinese, and Chinese in Thailand) by use of chi-square test, **: p < 0.05 (significant differences among Chinese, Indian, and Malay in Malaysia) by use of chi-square test.