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Table 2 Univariate and multivariate analyses of factors associated with time to HIV-1 RNA < 500 copies/mL among individuals beginning antiretroviral therapy

From: Physician experience and rates of plasma HIV-1 RNA suppression among illicit drug users: an observational study

Characteristic

Hazard Ratio

95% CI3

p-value

Adjusted Hazard Ratio

95% CI3

p-value

Physician experience1

      

   Per 100 patients

1.25

1.10-1.42

< 0.001

1.17

1.04-1.34

0.031

Age1

      

   Per 10 years

1.26

1.08-1.47

0.004

   

Gender1

      

   Female vs. male

0.95

0.73-1.24

0.711

   

Aboriginal ancestry1

      

   Yes vs. no

1.05

0.80-1.36

0.103

   

DTES residence2

      

   Yes vs. no

1.13

0.86-1.49

0.788

   

Methadone maintenance2

      

   Yes vs. no

1.54

1.18-2.00

0.001

1.61

1.23-2.09

< 0.001

Daily cocaine use2

      

   Yes vs. no

0.92

0.68-1.24

0.578

   

Daily heroin use2

      

   Yes vs. no

0.78

0.57-1.08

0.137

   

ART adherence2

      

   > 95% vs. ≤ 95%

4.12

3.10-5.54

< 0.001

2.42

1.80-3.26

< 0.001

PI in first regimen1

      

   Yes vs. no

1.23

0.95-1.61

0.117

   

CD4 cell count1

      

   Per 100 cells

0.90

0.84-0.96

0.003

0.89

0.83-0.96

0.001

Plasma viral load1

      

   Per log10 increase

0.71

0.58-0.87

0.001

0.65

0.53-0.81

< 0.001

Year of ART initiation1

      

   Per more recent year

1.17

1.12-1.21

< 0.001

   
  1. 1. Time invariant, observed at baseline
  2. 2. Time varying, observed every 6 months
  3. 3. 95% Confidence Interval
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BMC Infectious Diseases

ISSN: 1471-2334

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