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Table 2 Clinical manifestations, laboratory data, and outcome of 670 meningococcal disease patients with completed case records: serogroup C versus A

From: Emergence of serogroup C meningococcal disease associated with a high mortality rate in Hefei, China

Feature Serogroup C (n = 493) Serogroup A (n = 177)   P
onset     
  Presentation days (mean ± SD) 1.8 ± 2.5 1.9 ± 2.4   0.810
  Fever 481(97.6) 169(95.5)   0.162
  Nausea and/or vomiting 141(28.5) 55(31.2)   0.535
  Headache 165(33.4) 52(29.1)   0.319
  Petechia and/or purpura 396(80.3) 126(73.4)   0.063
  Altered mental status 136(27.6) 49(27.7)   0.980
Disease classification     
  Meningitis 114(23.1) 92(52.0)   <0.001
  Meningococcemia 379(76.9) 85(48.0)   
  With Shock 91(18.5) 13(7.3)   <0.001
  With pneumonia 12(2.8) 3(1.7)   0.784
  With arthritis 9 (1.8) 4(2.3)   0.967
Complications 161 23   <0.001
  Shock 91(18.5) 13(7.3)   <0.001
  DIC 60(12.2) 7(4.0)   0.002
  kidney failure 10(2) 3(1.7)   0.783
  MOF 4(0.8) 1(0.6)   1.0
WBC count     
  >10 × 109/L 302(61.3) 99(56.1)   0.019
  10~4 × 109/L 117(23.7) 35(19.8)   
  <4 × 109/L 74(15.0) 43(24.3)   
Platelet count     
  >100 × 109/L 361(73.2) 162(91.5)   <0.001
  100~50 × 109/L 87(17.6) 11(6.2)   
  100~50 × 109/L 87(17.6) 11(6.2)   
CSF data (mean ± SD)     
  Glucose level(mmol/L) 2.07 ± 1.7 1.91 ± 1.8   0.717
  CSF glucose / blood glucose ratio 0.24 ± 0.23 0.21 ± 0.29   0.438
  Total protein level(g/L) 3.41 ± 2.9 3.17 ± 2.18   0.106
  Lactate level(mmol/L) 10.4 ± 9.2 11.0 ± 8.9   0.113
  WBC count(109/L) 5.3 ± 13.8 8.1 ± 13.6   0.895
Sequelae 46/484(9.5) 6/171(3.5)   0.013
  Scars 19/484(3.9) 2/171(1.2)   0.132
  Amputations 14/484(2.9) 0   0.026
  sensorineural hearing loss 5/484(1.0) 3/171(1.8)   0.739
  Others 8/484(17) 1/171(0.6)   0.516
Death 55/484(11.4) 9/171(5.3)   0.021
  1. NOTE. Data are no. (%) of patients, unless otherwise indicated.
  2. WBC: white blood cells. DIC: disseminated intravascular coagulation.
  3. MOF: multiple organ failure.