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Table 2 Clinical manifestations, laboratory data, and outcome of 670 meningococcal disease patients with completed case records: serogroup C versus A

From: Emergence of serogroup C meningococcal disease associated with a high mortality rate in Hefei, China

Feature

Serogroup C (n = 493)

Serogroup A (n = 177)

 

P

onset

    

  Presentation days (mean ± SD)

1.8 ± 2.5

1.9 ± 2.4

 

0.810

  Fever

481(97.6)

169(95.5)

 

0.162

  Nausea and/or vomiting

141(28.5)

55(31.2)

 

0.535

  Headache

165(33.4)

52(29.1)

 

0.319

  Petechia and/or purpura

396(80.3)

126(73.4)

 

0.063

  Altered mental status

136(27.6)

49(27.7)

 

0.980

Disease classification

    

  Meningitis

114(23.1)

92(52.0)

 

<0.001

  Meningococcemia

379(76.9)

85(48.0)

  

  With Shock

91(18.5)

13(7.3)

 

<0.001

  With pneumonia

12(2.8)

3(1.7)

 

0.784

  With arthritis

9 (1.8)

4(2.3)

 

0.967

Complications

161

23

 

<0.001

  Shock

91(18.5)

13(7.3)

 

<0.001

  DIC

60(12.2)

7(4.0)

 

0.002

  kidney failure

10(2)

3(1.7)

 

0.783

  MOF

4(0.8)

1(0.6)

 

1.0

WBC count

    

  >10 × 109/L

302(61.3)

99(56.1)

 

0.019

  10~4 × 109/L

117(23.7)

35(19.8)

  

  <4 × 109/L

74(15.0)

43(24.3)

  

Platelet count

    

  >100 × 109/L

361(73.2)

162(91.5)

 

<0.001

  100~50 × 109/L

87(17.6)

11(6.2)

  

  100~50 × 109/L

87(17.6)

11(6.2)

  

CSF data (mean ± SD)

    

  Glucose level(mmol/L)

2.07 ± 1.7

1.91 ± 1.8

 

0.717

  CSF glucose / blood glucose ratio

0.24 ± 0.23

0.21 ± 0.29

 

0.438

  Total protein level(g/L)

3.41 ± 2.9

3.17 ± 2.18

 

0.106

  Lactate level(mmol/L)

10.4 ± 9.2

11.0 ± 8.9

 

0.113

  WBC count(109/L)

5.3 ± 13.8

8.1 ± 13.6

 

0.895

Sequelae

46/484(9.5)

6/171(3.5)

 

0.013

  Scars

19/484(3.9)

2/171(1.2)

 

0.132

  Amputations

14/484(2.9)

0

 

0.026

  sensorineural hearing loss

5/484(1.0)

3/171(1.8)

 

0.739

  Others

8/484(17)

1/171(0.6)

 

0.516

Death

55/484(11.4)

9/171(5.3)

 

0.021

  1. NOTE. Data are no. (%) of patients, unless otherwise indicated.
  2. WBC: white blood cells. DIC: disseminated intravascular coagulation.
  3. MOF: multiple organ failure.