Appraising the performance of genotyping tools in the prediction of coreceptor tropism in HIV-1 subtype C viruses

BMC Infectious Diseases

Table 2 Accuracy of genotyping approaches at correctly predicting coreceptor tropism

Method	CXCR4-using accuracy	CXCR4-exclusive accuracy	R5X4 accuracy
PSSM__sinsi	88	88	88
PSSM__X4R5	86	87	86
C-PSSM	91	90	91
Geno2Pheno__FPR5	94	93	94
Geno2Pheno__FPR10	92	91	92
Geno2Pheno__FPR20	88	87	90
WetCat__C4.5	70	70	70
WetCat__{C4.5 pos. 8&12}	70	70	70
WetCat__PART	77	76	79
WetCat__SVM	81	82	81
11/24/25	81	81	82
11/25	79	76	82
Raymond	86	88	85

Accuracy scores are presented for a combined dataset containing CXCR4-using viruses (both CXCR4-exclusive and dual-tropic viruses) as well as separately for the CXCR4-exclusive and dual-tropic viral sequences.

ISSN: 1471-2334