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Table 1 Performance of genotyping approaches at predicting CXCR4-usage in viral sequences from individuals infected with HIV-1 group M subtype C

From: Appraising the performance of genotyping tools in the prediction of coreceptor tropism in HIV-1 subtype C viruses

Method

CXCR4-using sensitivity (%)

Specificity

PSSM_sinsi

76

100

PSSM_X4R5

75

97

C-PSSM

90

92

Geno2Pheno_FPR5

89

99

Geno2Pheno_FPR10

89

94

Geno2Pheno_FPR20

91

86

WetCat_C4.5

40

99

WetCat_C4.5 pos. 8&12

40

100

WetCat_PART

55

100

WetCat_SVM

63

99

11/24/25

68

97

11/25

60

99

Raymond

97

76

  1. Sensitivity corresponds to the ability of the approach to predict CXCR4-use, while specificity corresponds to the ability to correctly predict CCR5-use.