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Table 1 Performance of genotyping approaches at predicting CXCR4-usage in viral sequences from individuals infected with HIV-1 group M subtype C

From: Appraising the performance of genotyping tools in the prediction of coreceptor tropism in HIV-1 subtype C viruses

Method CXCR4-using sensitivity (%) Specificity
PSSM_sinsi 76 100
PSSM_X4R5 75 97
C-PSSM 90 92
Geno2Pheno_FPR5 89 99
Geno2Pheno_FPR10 89 94
Geno2Pheno_FPR20 91 86
WetCat_C4.5 40 99
WetCat_C4.5 pos. 8&12 40 100
WetCat_PART 55 100
WetCat_SVM 63 99
11/24/25 68 97
11/25 60 99
Raymond 97 76
  1. Sensitivity corresponds to the ability of the approach to predict CXCR4-use, while specificity corresponds to the ability to correctly predict CCR5-use.