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Table 3 Performance of smears and PS-PCR analyses, and their combination, in the diagnosis of ATL

From: Polymorphism-specific PCR enhances the diagnostic performance of American tegumentary leishmaniasis and allows the rapid identification of Leishmania species from Argentina

Assay

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

Smear

70.5

100

99.9

73.6

PS-PCR

81

84.2

86.2

78.5

Smear + PS-PCR

97.61

83.3

87.9

91

  1. PPV = positive predictive values; NPV = negative predictive values, estimated applying the theorem of Bayes. The positive and negative PCR controls and the results from healthy individuals from non-endemic areas were not included in the calculations.1The differences between proportions were statistically significant (P = 0.0018) when the Smear + PS-PCR were compared against these tests alone.