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Table 1 Characteristics of the included patients

From: Doxycycline-mediated effects on persistent symptoms and systemic cytokine responses post-neuroborreliosis: a randomized, prospective, cross-over study

No Sex Age (years) Symptom duration before initial treatment (weeks) CSF total white cell count x 10 6/L Initial treatment of NB Re-LP [months after initial LP] (CSF white cell count x 10 6/L) Randomization Symptom duration at study inclusion (months) Symptoms at study inclusion
1 F 48 4 300 Doxycycline, Ceftriaxone 1 (33) Placebo, Doxycycline 82 Headache, myalgia, arthralgia, concentration and memory difficulties, depression, insomnia**
2 M 60 7 170 Doxycycline 2 (30) Doxycycline, Placebo 25 Fatigue (1), muscle weakness (2), headache, arthralgia, insomnia
3 M 38 8 20 Doxycycline 12 (0.5) Doxycycline, Placebo 57 Paresthesia, sound sensitivity, imbalance, depression**
4 M 70 2 560 Doxycycline, Ceftriaxone 10 (2.0) Doxycycline, Placebo 87 Hearing loss (1), discomfort of facial palsy (2), arthralgia, myalgia
5 F 59 7 570 Doxycycline, Ceftriaxone 0.75 (100) Placebo, Doxycycline 51 Neck pain (1), imbalance (2), paresthesia, headache
6 F 54 3 850 Ceftriaxone 1 (20) Doxycycline, Placebo 27 Hyperesthesia (1), eye twitching (2)
7 F 60 3 500 Doxycycline, Ceftriaxone 2 (8.0) Placebo, Doxycycline 75 Hearing loss (1), imbalance (2), headache, hypoesthesia
8 M 44 3 N.A♯ Doxycycline, Ceftriaxone 8 (3.0) Placebo, Doxycycline 102 Arthralgia (1), insomnia (2), headache, discomfort of facial palsy, paresthesia, muscle weakness, concentration and memory difficulties, depression
9 M 64 12 0.7♯♯ Doxycycline N.A Placebo, Doxycycline 11 Imbalance (1)
10 F 73 5 200 Doxycycline N.A Doxycycline, Placebo 13 Headache (1), fatigue (2)
11 M 65 13 190 Doxycycline, Ceftriaxone 0.5 (30) Doxycycline, Placebo 11 Paresthesia (1), neck pain (2), headache, myalgia, concentration difficulties, irritability
12 M 82 3 130 Doxycycline N.A Placebo, Doxycycline 11 Imbalance (1), back pain (2), headache, hearing loss, myalgia
13 M 48 4 200 Doxycycline 5 (3.0) Doxycycline, Placebo 24 Dysestesia (1), fatigue (2), headache, hearing loss, myalgia, concentration and memory difficulties
14 M 50 3 220 Doxycycline N.A Doxycycline, Placebo 16 Paresthesia (1), pain in extremity/radiculitis (2)
15 F 71 3 11* Doxycycline N.A Placebo, Doxycycline 13 Discomfort of bilateral facial palsy (1), paresthesia (2)
  1. The persistent symptoms include all the declared symptoms at inclusion, of which the ones in bold with numbers in parenthesis indicate the two symptoms with the highest symptom severity scores. F, female; M, male; No, number; CSF, cerebrospinal fluid; NB, neuroborreliosis; LP, lumbar puncture; N.A, not analyzed; ♯Only the intrathecal anti-borrelia antibody index was analyzed. ♯♯ LP was done one week after initiation of treatment. * LP was done 15 weeks after initiation of antibiotic treatment. ** Symptom severity score was not assessed.