No | Sex | Age (years) | Symptom duration before initial treatment (weeks) | CSF total white cell count x 10 6/L | Initial treatment of NB | Re-LP [months after initial LP] (CSF white cell count x 10 6/L) | Randomization | Symptom duration at study inclusion (months) | Symptoms at study inclusion |
---|---|---|---|---|---|---|---|---|---|
1 | F | 48 | 4 | 300 | Doxycycline, Ceftriaxone | 1 (33) | Placebo, Doxycycline | 82 | Headache, myalgia, arthralgia, concentration and memory difficulties, depression, insomnia** |
2 | M | 60 | 7 | 170 | Doxycycline | 2 (30) | Doxycycline, Placebo | 25 | Fatigue (1), muscle weakness (2), headache, arthralgia, insomnia |
3 | M | 38 | 8 | 20 | Doxycycline | 12 (0.5) | Doxycycline, Placebo | 57 | Paresthesia, sound sensitivity, imbalance, depression** |
4 | M | 70 | 2 | 560 | Doxycycline, Ceftriaxone | 10 (2.0) | Doxycycline, Placebo | 87 | Hearing loss (1), discomfort of facial palsy (2), arthralgia, myalgia |
5 | F | 59 | 7 | 570 | Doxycycline, Ceftriaxone | 0.75 (100) | Placebo, Doxycycline | 51 | Neck pain (1), imbalance (2), paresthesia, headache |
6 | F | 54 | 3 | 850 | Ceftriaxone | 1 (20) | Doxycycline, Placebo | 27 | Hyperesthesia (1), eye twitching (2) |
7 | F | 60 | 3 | 500 | Doxycycline, Ceftriaxone | 2 (8.0) | Placebo, Doxycycline | 75 | Hearing loss (1), imbalance (2), headache, hypoesthesia |
8 | M | 44 | 3 | N.A♯ | Doxycycline, Ceftriaxone | 8 (3.0) | Placebo, Doxycycline | 102 | Arthralgia (1), insomnia (2), headache, discomfort of facial palsy, paresthesia, muscle weakness, concentration and memory difficulties, depression |
9 | M | 64 | 12 | 0.7♯♯ | Doxycycline | N.A | Placebo, Doxycycline | 11 | Imbalance (1) |
10 | F | 73 | 5 | 200 | Doxycycline | N.A | Doxycycline, Placebo | 13 | Headache (1), fatigue (2) |
11 | M | 65 | 13 | 190 | Doxycycline, Ceftriaxone | 0.5 (30) | Doxycycline, Placebo | 11 | Paresthesia (1), neck pain (2), headache, myalgia, concentration difficulties, irritability |
12 | M | 82 | 3 | 130 | Doxycycline | N.A | Placebo, Doxycycline | 11 | Imbalance (1), back pain (2), headache, hearing loss, myalgia |
13 | M | 48 | 4 | 200 | Doxycycline | 5 (3.0) | Doxycycline, Placebo | 24 | Dysestesia (1), fatigue (2), headache, hearing loss, myalgia, concentration and memory difficulties |
14 | M | 50 | 3 | 220 | Doxycycline | N.A | Doxycycline, Placebo | 16 | Paresthesia (1), pain in extremity/radiculitis (2) |
15 | F | 71 | 3 | 11* | Doxycycline | N.A | Placebo, Doxycycline | 13 | Discomfort of bilateral facial palsy (1), paresthesia (2) |