From: Probable late lyme disease: a variant manifestation of untreated Borrelia burgdorferi infection
Characteristics | Confirmed Late (n=23) | Probable Late (n=13) | PLS (n=36) | Other diagnosis (n=35) | No specific diagnosis (n=128) |
---|---|---|---|---|---|
Demographics | |||||
Age at illness onset | 49.1 (44.9-65.3) | 56.6 (50-67) | 46.6 (35.5-52.5) | 55.4 (36.5-61.6) | 42.2 (32.1-53.0) |
Male Sex | 14/23 (61%) | 6/13 (46%) | 19/36 (53%) | 14/35 (40%) | 43/128 (34%) |
Illness duration (weeks) | 52 (9-130) | 63 (52-152) | 127 (30-270) | 52 (25-216) | 78 (40-204) |
Symptoms | |||||
Widespread musculoskeletal pain | 2/23 (9%) | 11/13 (85%) | 36/36 (100%) | 17/35 (49%) | 112/128 (88%) |
Fatigue | 0/23 (0%) | 8/13 (62%) | 32/36 (89%) | 15/35 (43%) | 96/128 (75%) |
Cognitive complaints | 0/23 (0%) | 6/13 (46%) | 19/36 (53%) | 8/35 (23%) | 67/128 (52%) |
Signs | |||||
Patient reported rash in absence of physician diagnosis of EM | 1/23 (4%) | 5/13 (38%) | 1/36 (3%) | 5/35 (14%) | 33/128 (26%) |
Physician documented EM | 1/23 (4%) | 0/13 (0%) | 26/36 (72%) | 4/35 (11%) | 1/128 (1%) |
Other physician documented objective findings | 21/23 (91%) | 0/13 (0%) | 9/36 (25%) | 2/35 (6%) | 11/128 (9%) |
Serology | |||||
% ELISA positive ( >.9) | 17/18 (94%) | 11/11 (100%) | 18/28 (64%) | 6/23 (26%) | 6/104 (6%) |
Median ELISA among those (+) | 3.5 | 2.0 | 1.8 | 1.75 | 1.4 |
% IgM immunoblot (+) | 14/22 (64%) | 2/11 (18%) | 14/31 (45%) | 4/28 (14%) | 32/109 (29%) |
Treatment | |||||
Non-recommended antibiotic | 8/23 (35%) | 4/13 (31%) | 14/36 (39%) | 6/35 (17%) | 43/128 (34%) |
Steroid | 3/23 (13%) | 2/13 (15%) | 9/36 (25%) | 5/35 (14%) | 19/128 (15%) |