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Table 4 Significant variables associated with latent tuberculosis infection (LTBI) stratified by tuberculin skin test (TST) or interferon-gamma release assays in 302 HIV-infected patients with no past or current tuberculosis (TB) nor LTBI

From: Contribution of Interferon gamma release assays testing to the diagnosis of latent tuberculosis infection in HIV-infected patients: A comparison of QuantiFERON-TB Gold In Tube, T-SPOT.TB and tuberculin skin test

  TST positive QFG or T-SPOT.TB Either TST, QFG or T-SPOT.TB All tests (TST, QFG and T.SPOT.TB (Mc) negative
  (n = 20) * (Mc) positive (Mc) positive  
   (n = 45) ** (n = 56) *** (n = 246)
Median CD4 cell/μl count (range) 630 (90-1650)† 580 (10-1740) ‡ 580 (10-1730) † 450 (10-1760)
CD4 cell count < 350/μl 4 (20) 9 (20)¢ 13 (23.2) 88 (35.8)
CD4 cell count < 500/μl 6 (30) 12 (26.5) ‡ 18 (32.1) § 135 (54.9)
Median time (year) from 1st HIV-positive test (range) 11.5 (0.1-27) †† 12 (0.1-25) c 12 (0.1-27) †† 9.5 (0.1-23)
Contact with patients with TB 13 (65) § 4 (8.9) 24 (42.9) †† 69 (28.2)
History of injection drug use 15 (75) † 24 (53.3) 33 (58.8) †† 105 (42.7)
History of prior prison stay 12 (60) ‡ 24 (53.3) 21 (37.1) § 39 (17.9)
Lived in a shelter or homeless 11 (55) ‡ 10 (25.2) 18 (32.1) 48 (19.5)
Hepatitis C virus co-infection 14 (70) ¢ 20 (44.5) 28 (50.0) 92 (37.7)
  1. NOTE. Data are no (%) of patients unless otherwise indicated.
  2. ART, antiretroviral therapy; BCG, Bacille Calmette-Guérin; QFG, QuantiFERON-TB Gold, Mc: Manufacturer’s interpretation criteria.
  3. The numbers printed in bold letters indicate the value of variables significantly associated with positive test results in univariate analyses: †† p = 0.04; † p = 0.02 § p = 0.002; ¢ p = 0.009; ‡ p < 0.001; * comparing TST positive (n = 20) with TST negative patients (n = 282); ** comparing QFG or T.SPOT.TB positive (n = 45) with QFG or T.SPOT-TB (Mc) negative patients (n = 257); *** comparing either TST, QFG or T-SPOT.TB (Mc) positive (n = 56) with all tests (TST, QFG and T.SPOT.TB-Mc) negative (n = 246).