Table 4 Significant variables associated with latent tuberculosis infection (LTBI) stratified by tuberculin skin test (TST) or interferon-gamma release assays in 302 HIV-infected patients with no past or current tuberculosis (TB) nor LTBI
TST positive | QFG or T-SPOT.TB | Either TST, QFG or T-SPOT.TB | All tests (TST, QFG and T.SPOT.TB (Mc) negative | |
|---|---|---|---|---|
(n = 20) * | (Mc) positive | (Mc) positive | ||
(n = 45) ** | (n = 56) *** | (n = 246) | ||
Median CD4 cell/μl count (range) | 630 (90-1650)† | 580 (10-1740) ‡ | 580 (10-1730) † | 450 (10-1760) |
CD4 cell count < 350/μl | 4 (20) | 9 (20)¢ | 13 (23.2) | 88 (35.8) |
CD4 cell count < 500/μl | 6 (30) | 12 (26.5) ‡ | 18 (32.1) § | 135 (54.9) |
Median time (year) from 1st HIV-positive test (range) | 11.5 (0.1-27) †† | 12 (0.1-25) c | 12 (0.1-27) †† | 9.5 (0.1-23) |
Contact with patients with TB | 13 (65) § | 4 (8.9) | 24 (42.9) †† | 69 (28.2) |
History of injection drug use | 15 (75) † | 24 (53.3) | 33 (58.8) †† | 105 (42.7) |
History of prior prison stay | 12 (60) ‡ | 24 (53.3) | 21 (37.1) § | 39 (17.9) |
Lived in a shelter or homeless | 11 (55) ‡ | 10 (25.2) | 18 (32.1) | 48 (19.5) |
Hepatitis C virus co-infection | 14 (70) ¢ | 20 (44.5) | 28 (50.0) | 92 (37.7) |