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Table 1 Baseline demographic and clinic characteristics of 373 HIV-infected patients undergoing tuberculin skin test, QuantiFERON-TB Gold and T-SPOT-TB testing, stratified according to past or current tuberculosis (TB) and previous positive tuberculin skin test (TST)

From: Contribution of Interferon gamma release assays testing to the diagnosis of latent tuberculosis infection in HIV-infected patients: A comparison of QuantiFERON-TB Gold In Tube, T-SPOT.TB and tuberculin skin test

  All patients (n = 373) Patients with past or current TB (n = 56) Patients with positive TST treated (n = 15) Patients with no past or current TB nor positive TST (n = 302) P value*
Demography      
Median age, years (range) 44 (15-85) 45 (21-74) 42 (27-50) 44 (15-85) NS
Sex, male 287 (76.9) 44 (78.6) 14 (93.3) 229 (75.8) NS
Origin from a country with high prevalence of TB 28 (7.5) 7 (12.5) 1 (6.7) 20 (6.7) NS
HIV-related factors      
Prior AIDS defining illness 144 (38.6) 50 (89.3) 4 (26.7) 92 (30.5) <0.001
Median CD4 cell count, cells/μl (range) 470 (10-1760) 350 442 (120-1200) 500 (10-1760) 0.02
   (10-1550)    
CD4 cell count < 200/μl 62 (16.6) 20 (35.7) 3 (20) 39 (12.9) <0.001
CD4 cell count < 350/μl 135 (36.2) 28 (50) 9 (60) 101 (33.4) 0.03
CD4 cell count < 500/μl 198 (53.1) 35 (62.5) 10 (66.7) 153 (50.7) 0.07
Median nadir CD4 cell count, cells/μl (range) 150 (5-1650) 70 (5-1220) 240 (42-500) 180 (5-1650) <0.001
Median HIV-1 ARN viral load, copies/ml (range) <50 (0-1 x 106) 115 (0-1 x 106) <50 (0-85486) <50 (0-1 x 106) NS
HIV-1 RNA viral load < 50 copies/ml 218 (58.4) 35 (49.3) 11 (74) 183 (60.6) NS
ART-naïve 95 (25.5) 24 (42.8) 13 (86.7) 77 (25.5) NS
Median time (years) since 1st HIV-positive test (range) 10 (0-27) 12 (0.1-22) 12 (3-24) 10 (0.1-27) 0.001
BCG vaccine 58 (15.8) 13 (23.2) 5 (33.3) 40 (13.9) 0.02
Risk factors for TB infection      
Contact with patients with TB 144 (38.7) 40 (71.4) 11 (17.3) 93 (30.9) <0.001
History of injection drug use 187 (50.1) 35 (62.5) 14 (93.3) 138 (45.7) 0.001
History of prior prison stay 102 (27.3) 29 (51.8) 13 (86.7) 60 (19.9) <0.001
Lived in a shelter or homeless 97 (26.0) 22 (39.2) 6 (40) 66 (21.9) <0.001
Diabetes mellitus 16 (4.3) 1 (1.1) 1 (6.7) 14 (4.6) NS
Others      
Hepatitis C virus co-infection 167 (45.1) 33 (58.9) 14 (93.3) 120 (40.0) <0.001
  1. NOTE. Data are no (%) of patients unless otherwise indicated; ART, antiretroviral therapy; BCG, Bacille Calmette-Guérin; * p-value compared the patients with past or current TB and previous positive TST with patients with no past or current TB nor positive TST.