Table 1 Baseline demographic and clinic characteristics of 373 HIV-infected patients undergoing tuberculin skin test, QuantiFERON-TB Gold and T-SPOT-TB testing, stratified according to past or current tuberculosis (TB) and previous positive tuberculin skin test (TST)
All patients (n = 373) | Patients with past or current TB (n = 56) | Patients with positive TST treated (n = 15) | Patients with no past or current TB nor positive TST (n = 302) | P value* | |
|---|---|---|---|---|---|
Demography | |||||
Median age, years (range) | 44 (15-85) | 45 (21-74) | 42 (27-50) | 44 (15-85) | NS |
Sex, male | 287 (76.9) | 44 (78.6) | 14 (93.3) | 229 (75.8) | NS |
Origin from a country with high prevalence of TB | 28 (7.5) | 7 (12.5) | 1 (6.7) | 20 (6.7) | NS |
HIV-related factors | |||||
Prior AIDS defining illness | 144 (38.6) | 50 (89.3) | 4 (26.7) | 92 (30.5) | <0.001 |
Median CD4 cell count, cells/μl (range) | 470 (10-1760) | 350 | 442 (120-1200) | 500 (10-1760) | 0.02 |
(10-1550) | |||||
CD4 cell count < 200/μl | 62 (16.6) | 20 (35.7) | 3 (20) | 39 (12.9) | <0.001 |
CD4 cell count < 350/μl | 135 (36.2) | 28 (50) | 9 (60) | 101 (33.4) | 0.03 |
CD4 cell count < 500/μl | 198 (53.1) | 35 (62.5) | 10 (66.7) | 153 (50.7) | 0.07 |
Median nadir CD4 cell count, cells/μl (range) | 150 (5-1650) | 70 (5-1220) | 240 (42-500) | 180 (5-1650) | <0.001 |
Median HIV-1 ARN viral load, copies/ml (range) | <50 (0-1 x 106) | 115 (0-1 x 106) | <50 (0-85486) | <50 (0-1 x 106) | NS |
HIV-1 RNA viral load < 50 copies/ml | 218 (58.4) | 35 (49.3) | 11 (74) | 183 (60.6) | NS |
ART-naïve | 95 (25.5) | 24 (42.8) | 13 (86.7) | 77 (25.5) | NS |
Median time (years) since 1st HIV-positive test (range) | 10 (0-27) | 12 (0.1-22) | 12 (3-24) | 10 (0.1-27) | 0.001 |
BCG vaccine | 58 (15.8) | 13 (23.2) | 5 (33.3) | 40 (13.9) | 0.02 |
Risk factors for TB infection | |||||
Contact with patients with TB | 144 (38.7) | 40 (71.4) | 11 (17.3) | 93 (30.9) | <0.001 |
History of injection drug use | 187 (50.1) | 35 (62.5) | 14 (93.3) | 138 (45.7) | 0.001 |
History of prior prison stay | 102 (27.3) | 29 (51.8) | 13 (86.7) | 60 (19.9) | <0.001 |
Lived in a shelter or homeless | 97 (26.0) | 22 (39.2) | 6 (40) | 66 (21.9) | <0.001 |
Diabetes mellitus | 16 (4.3) | 1 (1.1) | 1 (6.7) | 14 (4.6) | NS |
Others | |||||
Hepatitis C virus co-infection | 167 (45.1) | 33 (58.9) | 14 (93.3) | 120 (40.0) | <0.001 |