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Table 5 Multivariate analyses of the association between single and multiple human papillomavirus infections and selected subjects’ characteristics

From: Predictors of human papillomavirus infection in women undergoing routine cervical cancer screening in Spain: the CLEOPATRE study

 

Single infection vs. negative (n = 2845)

Multiple infection vs. negative (n = 2746)

No. tested

Adjusted model1

No. tested

Adjusted model1

POR

95% CI

POR

95% CI

Age group (years)

 18

268

3.1

1.4–6.8

257

3.7

1.2–11.8

 19

287

3.5

1.6–7.5

273

4.1

1.3–12.9

 20–21

382

3.1

1.5–6.5

369

4.0

1.3–12.5

 22–25

401

3.1

1.5–6.4

387

3.8

1.2–11.7

 26–35

301

2.4

1.1–4.9

279

1.5

0.4–4.9

 36–45

309

0.9

0.4–2.1

304

1.4

0.4–5.0

 46–55

464

1.1

0.5–2.5

451

0.97

0.3–3.5

 56–65

433

1

reference

426

1

reference

P-value for trend

 

<0.001

  

0.001

 

Residential area

 Rural

305

1

reference

301

1

reference

 Suburban

359

1.3

0.7–2.4

344

0.9

0.4–2.0

 Urban

2176

1.4

0.9–2.4

2097

1.0

0.6–1.9

 Unknown

5

-

-

4

-

-

P-value for trend

 

0.2

  

0.8

 

Country of birth

 Spain

2616

1

reference

2528

1

reference

 Other countries

229

2.0

1.3–3.0

218

2.2

1.3–3.5

Marital status

 Married

1120

1

reference

1097

1

reference

 Single

1073

2.4

1.5–4.1

1034

3.2

1.4–7.2

 Cohabiting

483

2.1

1.3–3.6

452

2.0

0.9–4.7

 Divorced/Separated

114

2.6

1.3–5.2

110

5.4

2.1–14.2

 Widowed

55

3.5

1.1–11.0

53

7.0

1.3–37.9

Level of education attainment

 No formal education

160

1

reference

162

1

reference

 Primary completed

600

1.3

0.6–3.0

584

0.7

0.3–1.5

 Secondary  completed

1139

1.3

0.6–2.8

1095

0.6

0.3–1.4

 University or higher

943

1.1

0.5–2.3

902

0.5

0.2–1.0

 Unknown

3

-

-

3

-

-

P-value for trend

 

0.4

  

0.03

 

Tobacco smoking status

 Never smoked

1478

1

reference

1438

1

reference

 Ex-smoker

412

1.1

0.7–1.7

398

1.0

0.5–1.8

 Current smoker

954

1.7

1.3–2.3

909

1.6

1.1–2.4

 Unknown

1

-

-

1

-

-

P-value for trend

 

<0.001

  

0.005

 

Ever use of condoms

 Never used

612

1

reference

582

1

reference

 Ex or current user

2233

0.7

0.4–1.0

2164

1.1

0.6–1.9

Systematic condom use in last 12 months*

 No

1761

1

reference

1707

1

reference

 Yes

921

0.8

0.6–1.1

880

0.7

0.5–1.0

 Unknown

12

-

-

11

-

-

Lifetime number of sexual partners

 1

1487

1

reference

1447

1

reference

 2

528

1.6

1.1–2.4

504

2.3

1.3–3.9

 3

337

3.4

2.3–5.0

319

6.0

3.5–10.2

 ≥4

482

3.7

2.6–5.4

466

8.1

5.0–13.3

 Unknown

11

-

-

10

-

-

p-value for trend

 

<0.001

  

<0.001

 

Age at first sexual intercourse (years)

 ≤14

104

0.7

0.2–2.3

100

0.4

0.1–2.4

 15–16

589

0.8

0.3–2.5

567

0.6

0.1–2.8

 17–18

973

0.9

0.3–2.6

941

0.7

0.1–3.3

 19–20

459

1.1

0.3–3.2

440

0.8

0.2–3.7

 21–25

567

1.4

0.5–4.2

548

1.0

0.2–4.8

 ≥26

138

1

reference

136

1

reference

 Unknown

15

-

-

14

-

-

P-value for trend

 

0.03

  

0.07

 

Current partner circumcised

 No

2138

1

reference

2079

1

reference

 Yes

343

0.9

0.6–1.4

327

0.7

0.4–1.3

 Unknown

364

-

-

340

-

-

History of genital warts

 No

2780

1

reference

2684

1

reference

 Yes

59

2.8

1.5–5.1

58

4.4

2.3–8.8

 Unknown

6

-

-

4

-

-

  1. POR, prevalence odds ratio; CI, confidence interval.
  2. 1Adjusted model: adjusted for age, Autonomous Community, country of birth, marital status, level of education, smoking habits, lifetime number of sexual partners, and history of genital warts.
  3. *Among women with a sexual partner in the last 12 months.
  4. Bold font indicates a significant effect (P < 0.05).