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Table 2 Lung cytokine and chemokine levels in splenectomized WT and TLR2KO mice 24 hours after intranasal infection with serotype 3S. pneumoniae

From: The role of TLR2 in the host response to pneumococcal pneumonia in absence of the spleen

  WT TLR2 KO
TNF-α 1619 ± 277 1482 ± 536
IL-1β 261 ± 53 203 ± 75
MIP-2 2842 ± 216 2076 ± 216 *
KC 6767 ± 2446 4167 ± 1197
  1. Whole lung homogenates were obtained at 24 hours after intranasal infection with 7*104 CFU of S. pneumoniae serotype 3 (ATCC). Data are means ± SEM (N = 7–8 per group).
  2. * indicates p < 0,05 versus WT mice, ** indicate p < 0,005 versus WT mice.
  3. TNF-α, IL-1β, MIP-2 and KC values are in pg/ml.