Lung pathology induced by serotype 2 S. pneumoniae. Representative slides of lung tissue obtained at 6 hours (upper panels; A. WT and B. TLR2KO) and 24 hours (lower panels; D. WT and E. TLR2KO) after infection with 6*105 CFU S. pneumoniae (D39). Haematoxylin and eosin staining. Magnification 10x. Insets: representative slides of lung Ly-6 G staining (brown), showing influx of neutrophils. Findings are quantified by total pathology scores (total lung inflammation scores, TLIS) and scores of pulmonary Ly-6 G at 6 hours (C), and 24 hours (F) after induction of pneumococcal pneumonia. Data are expressed as means ± SE (3–7 mice per group).