(Mag. 165 K). Classical EL case #21225. Cytoplasm of a neuron: VLP. This image illustrates the VLP in the cytoplasm of neurons in the EL cases. VLP were found only in the neurons of the cases of classical EL, modern EL, and PEP. A constant finding was the presence of ER membranes embedded in putative virus factories (arrows). The membranes were of varying length and were in association with small budding particles. VLP were also found embedded in putative virus factories. On comparing the cytoplasmic VLP in Figure 3 with ribosomes in a neuron in a modern normal brain in Figure 2, the VLP on visual inspection appear larger than the ribosomes. The difference on measurement of VLP and ribosomes is statistically significant (see Statistical Comparison of Particle Diameters). Additionally, the standard deviation results for the measurements of the VLP and normal ribosomes showed greater variation in the diameter of the VLP than that of ribosomes from modern control brain. This is consistent with measurements of VLP in various stages of assembly (see Figures 4, 5, 6, 7, 8, 9 and 10). Bar = 100 nm.