(Mag. 74K). Intranuclear replication of coxsackievirus B in cell culture. Figure 14 is a TEM image of a coxsackie B infected cell culture showing the intranuclear site of coxsackievirus B replication after 7 h incubation. Two types of particle are demonstrated in this TEM. Small particles are scattered throughout a virus factory, as well as occasional large particles. Large particles measuring approximately 50 nm are observed surrounding another virus factory. SVP = small virus particles. LVP = large virus particles, indicated by arrow. VF = virus factory. Bar = 100 nm.