Figure 1
Effects of ATL 370 alone on C. difficile toxin A-induced secretion and epithelial injury. Increasing doses of intravenous ATL 370 (adenosine A2A receptor agonist; ng) decreased toxin A (10 μg)-induced intraluminal fluid accumulation (A) and histopathology scores (B) in rabbit ileal loops. Panel 1A: a- P < 0.0001 (one-way ANOVA), and b(PBS vs. Toxin A)- P < 0.001, c(Toxin A vs ATL150)- P < 0.01 (Bonferroni's). Panel 1B: a- P < 0.0001 (one-way ANOVA), b(PBS vs. Toxin A) - P < 0.001 (Bonferroni's), c (Toxin A vs ATL15)- P = 0.04 (Unpaired t-test with Welch's). Results were data pooled from 8 to 28 loops from 2 to 5 rabbits per group from 5 separate experiments.