| | |
Subjects ages
|
Subjects ages
|
Subjects ages
|
Subjects ages
|
|---|
| |
Total study population
|
3–5 years
|
6–17 years
|
18–49 years
|
50–80 years
|
|---|
|
Variable
|
(n = 789)
|
(n = 65)
|
(n = 197)
|
(n = 326)
|
(n = 201)
|
|---|
|
Outcome variables
|
n (%)
|
n (%)
|
n (%)
|
n (%)
|
n (%)
|
|
Influenza diagnosis
| | | | | |
|
Positive
|
220 (27.9)
|
12 (18.5)
|
65 (33.0)
|
92 (28.2)
|
51 (25.4)
|
|
Negative
|
569 (72.1)
|
53 (81.5)
|
132 (67.0)
|
234 (71.8)
|
150 (74.6)
|
|
Influenza type
| | | | | |
|
A
|
152 (69.1)
|
7 (58.3)
|
53 (81.5)
|
63 (68.5)
|
29 (56.9)
|
|
B
|
67 (30.5)
|
5 (41.7)
|
11 (16.9)
|
29 (31.5)
|
22 (43.1)
|
|
AB
|
1 (0.5)
|
0 (0.0)
|
1 (1.5)
|
0 (0.0)
|
0 (0.0)
|
|
Influenza A subtypea
| | | | | |
|
H1
|
51 (44.0)
|
3 (42.9)
|
19 (44.2)
|
18 (38.3)
|
11 (57.9)
|
|
H3
|
46 (39.7)
|
1 (14.3)
|
21 (48.8)
|
17 (36.2)
|
7 (36.8)
|
|
Unsubtypeable
|
19 (16.4)
|
3 (42.9)
|
3 (7.0)
|
12 (25.5)
|
1 (5.3)
|
|
Continuous variables
|
Value (error)b
|
Value (error)b
|
Value (error)b
|
Value (error)b
|
Value (error)b
|
|
Age (years)
|
31.2 (19.4)
|
4.0 (0.8)
|
11.5 (3.6)
|
32.0 (9.9)
|
56.8 (5.3)
|
|
Symptom duration (days)
|
4.0 (1–90)
|
4.0 (1–30)
|
3.0 (1–60)
|
5.0 (1–60)
|
5.0 (1–90)
|
|
Temperature (°C)
|
36.9 (35.6–40.3)
|
36.8 (35.9–39.5)
|
37.1 (35.6–40.3)
|
36.9 (35.9–39.6)
|
36.8 (35.6–39.3)
|
|
Smoking history (pack-years)
|
0.0 (0–117.5)c
|
––d
|
––d
|
0.0 (0–51)c
|
0.0 (0–117.5)
|
|
Vaccine to Onset Time (Days)e
|
80 (0–365)
|
57 (0–198)
|
74 (6–348)
|
89 (3–342)
|
85.4 (8–365)
|
|
Categorical variables
|
n (%)
|
n (%)
|
n (%)
|
n (%)
|
n (%)
|
|
Enrollment site
| | | | | |
|
Outpatient clinic 1
|
284 (36.0)
|
6 (9.2)
|
61 (31.0)
|
137 (42.0)
|
80 (39.8)
|
|
Outpatient clinic 2
|
203 (25.7)
|
15 (23.1)
|
55 (27.9)
|
63 (19.3)
|
70 (34.8)
|
|
Emergency room
|
246 (31.2)
|
24 (36.9)
|
47 (23.9)
|
124 (38.0)
|
51 (25.4)
|
|
Pediatric clinic
|
56 (7.1)
|
20 (30.8)
|
34 (17.3)
|
2 (0.6)
|
0 (0.0)
|
|
Sex
| | | | | |
|
Female
|
494 (62.6)
|
30 (46.2)
|
87 (44.2)
|
270 (82.8)
|
107 (53.2)
|
|
Male
|
295 (37.4)
|
35 (53.8)
|
110 (55.8)
|
56 (17.2)
|
94 (46.8)
|
|
Acute onset
| | | | | |
|
≤3 days
|
273 (34.6)
|
30 (46.2)
|
99 (50.3)
|
100 (30.7)
|
44 (21.9)
|
|
>3 days
|
516 (65.4)
|
35 (53.8)
|
98 (49.8)
|
226 (69.3)
|
157 (78.1)
|
|
Fever
| | | | | |
|
>38.0°C
|
126 (16.0)
|
11 (16.9)
|
48 (24.4)
|
43 (13.2)
|
24 (11.9)
|
|
≤38.0°C
|
663 (84.0)
|
54 (83.1)
|
149 (75.6)
|
283 (86.8)
|
177 (88.1)
|
|
Cough
| | | | | |
|
Yes
|
736 (93.3)
|
63 (96.9)
|
176 (89.3)
|
299 (91.7)
|
198 (98.5)
|
|
No
|
53 (6.7)
|
2 (3.1)
|
21 (10.7)
|
27 (8.3)
|
3 (1.5)
|
|
Sore throat
| | | | | |
|
Yes
|
630 (79.8)
|
33 (50.8)
|
170 (86.3)
|
278 (85.3)
|
149 (74.1)
|
|
No
|
159 (20.2)
|
32 (49.2)
|
27 (13.7)
|
48 (14.7)
|
52 (25.9)
|
|
Shortness of breathe
| | | | | |
|
Yes
|
346 (43.9)
|
20 (30.8)
|
73 (37.2)
|
166 (50.9)
|
87 (43.3)
|
|
No
|
442 (56.0)
|
45 (69.2)
|
123 (62.8)
|
160 (49.1)
|
114 (56.7)
|
|
Nasal congestion
| | | | | |
|
Yes
|
650 (82.4)
|
51 (78.5)
|
155 (78.7)
|
271 (83.1)
|
173 (86.1)
|
|
No
|
139 (17.6)
|
14 (21.5)
|
42 (21.3)
|
55 (16.9)
|
28 (13.9)
|
|
Headache
| | | | | |
|
Yes
|
619 (78.5)
|
31 (47.7)
|
134 (68.0)
|
286 (87.7)
|
168 (83.6)
|
|
No
|
170 (21.5)
|
34 (52.3)
|
63 (32.8)
|
40 (12.3)
|
33 (16.4)
|
|
Conjunctivitise
| | | | | |
|
Yes
|
44 (5.6)
|
6 (9.2)
|
4 (2.0)
|
16 (4.9)
|
18 (9.0)
|
|
No
|
744 (94.3)
|
59 (90.8)
|
193 (98.0)
|
309 (94.8)
|
183 (91.0)
|
|
Body achese
| | | | | |
|
Yes
|
581 (73.6)
|
27 (41.5)
|
99 (50.2)
|
289 (88.7)
|
166 (82.6)
|
|
No
|
207 (26.2)
|
37 (56.9)
|
98 (49.8)
|
37 (11.4)
|
35 (17.4)
|
|
Nausea/vomiting
| | | | | |
|
Yes
|
347 (44.0)
|
19 (29.2)
|
107 (54.3)
|
155 (47.5)
|
66 (32.8)
|
|
No
|
442 (56.0)
|
46 (70.8)
|
90 (45.7)
|
171 (52.5)
|
135 (67.2)
|
|
Smoker
| | | | | |
|
Yes
|
157 (19.9)
|
0 (0.0)
|
0 (0.0)
|
88 (27.0)
|
69 (34.3)
|
|
No
|
632 (80.1)
|
65 (100.0)
|
197 (100. 0)
|
238 (73.0)
|
132 (65.7)
|
|
Vaccinated
| | | | | |
|
Yes
|
217 (27.5)
|
17 (26.2)
|
27 (13.7)
|
85 (26.1)
|
88 (43.8)
|
|
No
|
572 (72.5)
|
48 (73.9)
|
170 (86.3)
|
241 (73.9)
|
113 (56.2)
|
- NOTE. Percentages are rounded, thus may not add up to 100%. aDenominator is subjects with at least one specimen positive by culture for influenza A. bContinuous variable values reported as “mean (standard deviation)” if symmetric variable, or “median (low end–high end of range)” if nonsymmetric. cTwo subjects in age group reported history of smoking but datum for number of pack-years is missing. dIn this age group no subjects reported pack-years >0. eMedian (range) reported for subset of subjects who reported any influenza vaccine within the 12 months prior to presentation. fDatum missing for 1 subject in study population.
