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Table 1 Characteristics of patients with macrolide-resistant (MR) and macrolide-sensitive (MS) Mycoplasma pneumoniae pneumonia in different age groups

From: Macrolide-resistant Mycoplasma pneumoniae in adolescents with community-acquired pneumonia

Characteristic Pediatric patients Adolescent patients Adult patients
MR MS MR MS MR MS
Number 30 15 12 14 7 21
Age range, years 1–15 1–15 16–19 16–19 20–42 28–45
Male:female 16:14 7:8 6:6 8:6 4:3 11:10
Mutation site in 23S rRNA a
  A2063G 26   10   6  
  A2064G 4   2   1  
No. of patients prescribed macrolides (%) 23 (76) 15 (100) 9 (75) 9 (64) 5 (71) 6 (28)
  Clarithromycin 12 10 5 4 2 2
  Azithromycin 11 5 4 5 3 4
No. of patients with a change of prescription after macrolide administration (%) 20 (66) 0 7 (58) 3 (21) 3 (42) 4 (19)
  Minocycline 16   5 3 1 1
  Quinolones 4 b   2 0 2 3
Clinical symptoms and laboratory findings at the first examination
  Cough 30 15 12 14 7 21
  Sputum 23 11 7 8 4 12
  Fever, temperature ≥ 38°C 26 14 11 13 7 21
  Respiratory rate, > 30/min 2 1 0 0 0 0
  White Blood Cell, mean (/uL) 6,410 6,520 6,810 7,010 6,620 6,710
  C-reactive protein, mean (mg/dL) 2.1 1.9 3.1 3.3 3.7 3.5
  1. a A2063G: A-to-G transition at position 2063 in domain V on the 23S rRNA gene.
  2. A2064G: A-to-G transition at position 2064.
  3. b Tosufloxacin used.