Efficacy of sodium butyrate adjunct therapy in shigellosis: a randomized, double-blind, placebo-controlled clinical trial

Table 3 Comparison of rectal inflammation between Intervention and Placebo groups of patients with shigellosis ^a

Assessment of Inflammation on day 7	Number of patients improved n (%) compared to day 1		Odds ratio^b(95% CI)	p value^b	Number of patients healed n (%) compared to day 1		Odds ratio^b(95% CI)	p value^b
Assessment of Inflammation on day 7	Intervention group	Placebo group	Odds ratio^b(95% CI)	p value^b	Intervention group	Placebo group	Odds ratio^b(95% CI)	p value^b
By sigmoidoscopy	11 (73.3)	6 (54.5)	2.29	0.324	9 (60)	4 (36)	2.63	0.239
By sigmoidoscopy	n = 15	n = 11	(0.4-11.9)	0.324	n = 15	n = 11	(0.5-13.1)	0.239
By histology	13 (92.8)	5 (50)	13	0.035	11 (78.6)	1(10)	33	0.005
	n = 14^c	n = 10^c	(1.2-140.7)		n = 14^c	n = 10^c	(2.9-374.3)

Abbreviation: CI Confidence interval.
^aData are given as number of patients (% of total patients in each group).
^bChi-square test was used to compare between groups. Significance: p≤ 0.05.
^cOne patient in the Intervention and one in the Placebo group did not have histological feature of inflammation on day 1 and thus excluded from the analysis.

ISSN: 1471-2334