Table 5 Herpes zoster- related complication rates in Primary Care

Upper respiratory tract. ENT complications

Otitis media

203

6.02

(5.27-6.88)

6.0

5.2

6.3

1.77*

(0.90-2.64)

3.55*

(1.73-5.37)

Upper respiratory tract infection

350

10.38

(9.40-11.46)

8.9

12.3

14.7

5.55*

(4.45-6.63)

7.96*

(5.24-10.69)

Sum of complications

553

16.40

(15.19-17.69)

14.9

17.5

21.0

7.32

11.51

Total number of patients^a

501

14.86

(13.70-16.10)

Eye complications

Keratitis

13

0.39

(0.23-0.66)

0.3

0.0

0.8

0.39*

(0.18-0.59)

0.64*

(0.13-1.16)

Conjunctivitis

48

1.42

(1.08-1.88)

1.4

2.4

1.4

1.42*

(1.02-1.82)

1.08*

(0.14-2.01)

Problems Eyelids

96

2.85

(2.34-3.47)

2.5

4.7

3.6

2.83*

(2.26-3.39)

3.76*

(2.50-5.02)

Visus

18

0.53

(0.34-0.84)

0.4

0.9

0.8

0.53*

(0.29-0.78)

0.86*

(0.27-1.45)

Sum of complications

175

5.19

(4.49-5.99)

4.6

8.0

6.6

5.17

6.34

Total number of patients^a

147

4.36

(3.72-5.10)

Lower respiratory tract complications

Pneunomia

15

0.44

(0.27-0.73)

0.2

0.9

1.0

0.30*

(0.07-0.53)

0.65

(−0.08-1.37)

Bronchitis

50

1.48

(1.13-1.95)

1.3

2.8

1.8

0.65*

(0.21-1.08)

0.21

(−1.53-1.11)

Sum of complications

65

1.93

(1.52-2.45)

1.5

3.7

2.8

0.95

0.86

Total number of patients^a

64

1.90

(1.49 2.42)

Skin infectious/cutaneous complications

Phlegmon

13

0.39

(0.23-0.66)

0.4

0.0

0.6

0.29*

(0.08-0.51)

0.22

(−0.30-0.73)

Pyoderma

13

0.39

(0.23-0.66)

0.4

0.0

0.4

0.30*

(0.08-0.51)

0.11

(−0.36-0.58)

Abscess

30

0.89

(0.62-1.27)

0.8

1.9

0.8

0.57*

(0.24-0.90)

0.86*

(0.13-1.59)

Skin infection

32

0.95

(0.67-1.34)

0.9

0.0

1.4

0.77*

(0.43-1.10)

0.86*

(0.13-1.59)

Cellulitis

21

0.62

(0.41-0.95)

0.6

1.4

0.4

0.55*

(0.28-0.82)

0.43

(−0.16-1.02)

Scar Tissue

46

1.36

(1.02-1.82)

1.3

0.5

1.9

0.57*

(0.15-0.99)

0.97*

(0.01-1.93)

Impetigo

112

3.32

(2.77-3.98)

3.9

1.4

1.8

2.65*

(2.03-3.27)

1.61*

(0.75-2.47)

Sum of complications

267

7.92

(7.06-8.88)

8.3

5.2

7.3

5.7

5.06

Total number of patients^a

234

6.94

(6.13 7.85)

PHN

PHN

195

5.78

(5.05 6.62)

3.4

8.0

13.1

5.78*

(5.00-6.57)

11.92*

(9.84-14.00)

Neurologic complications other than PHN

Syncope

27

0.80

(0.55-1.16)

0.5

0.5

1.8

0.38*

(0.06-0.70)

1.50*

(0.72-2.29)

Neuralgia (Trigeminal)

75

2.22

(1.78-2.78)

1.8

2.8

3.5

2.21*

(1.71-2.71)

3.33*

(2.18-4.48)

Meningitis

2

0.15

(0.02-0.22)

0.2

0.0

0.1

0.14

(−0.03-0.14)

0.11

(−0.10-0.32)

Ataxia (Cerebellitis)

1

0.03

(0.01-0.17)

0.04

0.0

0.0

0.03

(−0.03-0.09)

0.00

Movement and stability dysfunct.

6

0.18

(0.08-0.39)

0.1

0.0

0.6

0.18*

(0.04-0.32)

0.43*

(0.01-0.85)

Vertigo

97

2.88

(2.36-3.50)

2.3

1.9

5.0

2.36*

(1.79-2.94)

3.12*

(1.64-4.59)

Facial palsy

33

0.98

(0.70-1.37)

0.8

0.0

1.8

0.98*

(0.65-1.31)

1.40*

(0.64-2.15)

Coma

1

0.03

(0.01-0.17)

0.0

0.0

0.0

0.03

(−0.03-0.09)

0.00

Pain face

24

0.71

(0.48-1.06)

0.5

0.9

1.3

0.69*

(0.41-0.97)

1.18*

(0.49-1.88)

Sum of complications

266

7.89

(7.03-8.85)

6.24

6.1

14.1

7.00

11.07

Total number of patients^a

258

7.65

(6.80-8.60)

Gastrointestinal tract complications

Stomatitis

9

0.27

(0.14-0.51)

0.2

0.5

0.3

0.24*

(0.06-0.41)

0.43*

(0.01-0.85)

Gastroenteritis

52

1.54

(1.18-2.02)

1.2

3.3

2.2

0.63*

(0.18-1.07)

1.18

(−0.05-2.42)

Pancreatitis

10

0.30

(0.16-0.55)

0.1

1.9

0.6

0.25*

(0.07-0.44)

0.86*

(0.27-1.45)

Sum of complications

71

2.11

(1.67-2.65)

1.5

5.7

3.1

1.12

2.47

Total number of patients^a

66

1.96

(1.54-2.48)

Complications due to (systemic) bacterial infections

Sepsis

1

0.03

(0.01-0.17)

0.04

0.0

0.0

0.02

(−0.04-0.08)

0.00

Pyogen arthritis

3

0.09

(0.03-0.26)

0.08

0.5

0.0

0.09

(−0.01-0.19)

0.11

(−0.10-0.32)

Sum of complications

4

0.12

(0.05-0.30)

0.1

0.5

0.0

0.11

0.11

Total number of patients^a

4

0.12

(0.05-0.30)

Symptoms

Coughing

241

7.15

(6.33-8.07)

6.1

7.5

10.7

3.29*

(2.36-4.22)

6.88*

(4.66-9.11)

Snivelling

26

0.77

(0.53-1.13)

0.7

0.5

1.0

0.46*

(0.15-0.77)

0.54

(−0.16-1.23)

Fever

703

20.85

(19.52-22.26)

20.5

20.8

22.0

12.41*

(10.95-13.85)

16.23*

(13.21-19.25)

Fatigue

148

4.39

(3.75-5.14)

4.2

1.9

5.8

2.80*

(2.08-3.52)

3.23*

(1.60-4.85)

Emesis/Vomiting

121

3.59

(3.01-4.27)

3.0

3.3

5.6

2.15*

(1.49-2.81)

4.30*

(2.79-5.81)

Pruritis/Itching

1.005

29.81

(28.29-31.38)

31.7

17.9

26.8

22.64*

(21.03-24.23)

17.20*

(13.95-20.46)

Skin rash/Exanthema

400

11.87

(10.82-13.00)

11.2

13.2

13.6

11.00*

(9.89-12.09)

12.78*

(10.52-15.05)

Dehydration/Diarreah

106

3.14

(2.61-3.79)

2.6

2.4

5.3

1.58*

(1.03-2.27)

3.76*

(2.29-5.23)