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Table 3 Previous medication in patients infected with tcdA-positive tcdB-positive (A+B+) strains of Clostridium difficile and with tcdA-negative tcdB-positive (A-B+) strains

From: Clinical and microbiologic characteristics of tcdA-negative variant clostridium difficile infections

   A+B+ (n = 101) A-B+ (n = 21) P value a
Medication
  PPI N (%) 35 (34.7) 6 (28.6) 0.800
  H2 blockers N (%) 49 (48.5) 8 (38.1) 0.474
  Probiotics N (%) 49 (48.5) 13 (61.9) 0.339
  Steroids N (%) 37 (36.6) 7 (33.3) 1.000
  Chemotherapy N (%) 12 (11.9) 3 (14.3) 0.722
Antibiotics
  All-DDD Mean (SD) 25.4 (18.91) 27.0 (21.83) 0.989
  Days of antibiotic use Mean (SD) 18.7 (12.25) 16.6 (12.23) 0.317
Antibiotics use
  Fluoroquinolones N (%) 46 (45.5) 14 (66.7) 0.096
   2nd Quinolones N (%) 22 (21.8) 8 (38.1) 0.161
   3rd Quinolones N (%) 34 (33.7) 9 (42.9) 0.458
  Clindamycin N (%) 17 (16.8) 11 (52.4) 0.001
  ESC N (%) 57 (56.4) 11 (52.4) 0.811
  BL/BLI N (%) 36 (35.6) 6 (28.6) 0.620
  Carbapenem N (%) 10 (9.9) 2 (9.5) 1.000
  Glycopeptides N (%) 20 (19.8) 2 (9.5) 0.360
  Metronidazole N (%) 29 (28.7) 3 (14.3) 0.275
  Antibiotics dose     
  Fluoroquinolones Mean (SD) 5.606 (9.2145) 7.138 (10.0394) 0.202
   2nd Quinolones Mean (SD) 1.858 (5.1504) 2.210 (4.7322) 0.168
   3rd Quinolones Mean (SD) 3.737 (7.2372) 4.929 (9.3117) 0.484
  Clindamycin Mean (SD) 1.111 (3.1081) 4.302 (5.1853) <0.0001
  ESC Mean (SD) 5.260 (7.7728) 3.595 (4.5188) 0.611
  BL/BLI Mean (SD) 3.825 (9.2440) 3.536 (8.2533) 0.611
  Carbapenem Mean (SD) 0.636 (3.3368) 0.524 (1.7210) 0.995
  Glycopeptides Mean (SD) 1.255 (3.4253) 0.548 (1.9359) 0.270
  Metronidazole Mean (SD) 2.850 (6.9772) 1.397 (3.7901) 0.194
  1. A+B+, tcdA-positive tcdB-positive strain; A-B+, tcdA-negative tcdB-positive strain; PPI, proton pump inhibitor; DDD, defined daily dose; ESC, extended-spectrum cephalosporins; BL/BLI, beta-lactam/beta-lactamase inhibitor.
  2. a From Fisher’s exact test for categorical variables or the Mann–Whitney U-test for continuous variables.