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Table 3 Previous medication in patients infected with tcdA-positive tcdB-positive (A+B+) strains of Clostridium difficile and with tcdA-negative tcdB-positive (A-B+) strains

From: Clinical and microbiologic characteristics of tcdA-negative variant clostridium difficile infections

  

A+B+ (n = 101)

A-B+ (n = 21)

P value a

Medication

  PPI

N (%)

35 (34.7)

6 (28.6)

0.800

  H2 blockers

N (%)

49 (48.5)

8 (38.1)

0.474

  Probiotics

N (%)

49 (48.5)

13 (61.9)

0.339

  Steroids

N (%)

37 (36.6)

7 (33.3)

1.000

  Chemotherapy

N (%)

12 (11.9)

3 (14.3)

0.722

Antibiotics

  All-DDD

Mean (SD)

25.4 (18.91)

27.0 (21.83)

0.989

  Days of antibiotic use

Mean (SD)

18.7 (12.25)

16.6 (12.23)

0.317

Antibiotics use

  Fluoroquinolones

N (%)

46 (45.5)

14 (66.7)

0.096

   2nd Quinolones

N (%)

22 (21.8)

8 (38.1)

0.161

   3rd Quinolones

N (%)

34 (33.7)

9 (42.9)

0.458

  Clindamycin

N (%)

17 (16.8)

11 (52.4)

0.001

  ESC

N (%)

57 (56.4)

11 (52.4)

0.811

  BL/BLI

N (%)

36 (35.6)

6 (28.6)

0.620

  Carbapenem

N (%)

10 (9.9)

2 (9.5)

1.000

  Glycopeptides

N (%)

20 (19.8)

2 (9.5)

0.360

  Metronidazole

N (%)

29 (28.7)

3 (14.3)

0.275

  Antibiotics dose

    

  Fluoroquinolones

Mean (SD)

5.606 (9.2145)

7.138 (10.0394)

0.202

   2nd Quinolones

Mean (SD)

1.858 (5.1504)

2.210 (4.7322)

0.168

   3rd Quinolones

Mean (SD)

3.737 (7.2372)

4.929 (9.3117)

0.484

  Clindamycin

Mean (SD)

1.111 (3.1081)

4.302 (5.1853)

<0.0001

  ESC

Mean (SD)

5.260 (7.7728)

3.595 (4.5188)

0.611

  BL/BLI

Mean (SD)

3.825 (9.2440)

3.536 (8.2533)

0.611

  Carbapenem

Mean (SD)

0.636 (3.3368)

0.524 (1.7210)

0.995

  Glycopeptides

Mean (SD)

1.255 (3.4253)

0.548 (1.9359)

0.270

  Metronidazole

Mean (SD)

2.850 (6.9772)

1.397 (3.7901)

0.194

  1. A+B+, tcdA-positive tcdB-positive strain; A-B+, tcdA-negative tcdB-positive strain; PPI, proton pump inhibitor; DDD, defined daily dose; ESC, extended-spectrum cephalosporins; BL/BLI, beta-lactam/beta-lactamase inhibitor.
  2. a From Fisher’s exact test for categorical variables or the Mann–Whitney U-test for continuous variables.