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Table 1 Demographic and clinical characteristics of patients infected with Clostridium difficile tcdA-positive tcdB-positive (A+B+) strains and with tcdA-negative tcdB-positive (A-B+) strains

From: Clinical and microbiologic characteristics of tcdA-negative variant clostridium difficile infections

   A+B+ (n = 105) A-B+ (n = 22) p value a
Sex (female) N (%) 54 (51.4) 8 (36.4) 0.244
Age Mean (SD) 65.2 (15.10) 58.5 (19.12) 0.143
Length of hospital stay Mean (SD) 34.8 (44.41) 24.3 (21.20) 0.583
Charlson score Mean (SD) 3.17 (2.482) 2.50 (2.345) 0.172
Underlying disease
  COPD N (%) 8 (7.6) 5 (22.7) 0.049
  CVA N (%) 28 (26.7) 2 (9.1) 0.100
Surgical procedure N (%) 28 (26.7) 2 (9.1) 0.100
Severity score Mean (SD) 0.96 (0.746) 1.00 (0.873) 0.961
  Old age b N (%) 67 (63.8) 12 (54.5) 0.472
  Fever c N (%) 10 (9.5) 5 (22.7) 0.137
  Hypoalbuminemia d N (%) 10 (9.5) 1 (4.5) 0.688
  Leukocytosis e N (%) 14 (13.3) 4 (18.2) 0.515
  Severe CDI f N (%) 20 (19.0) 4 (18.2) 0.925
Clinical findings
  Pain N (%) 25 (23.8) 10 (45.5) 0.063
  Tenderness N (%) 36 (34.3) 10 (45.5) 0.338
  Stool Fr ≥10/day N (%) 21 (20.4) 2 (9.1) 0.362
  Mucoid stool N (%) 19 (18.1) 8 (36.4) 0.083
Laboratory findings
  WBC (cells/mm3) Mean (SD) 10892 (5527) 10263 (7746) 0.239
  Albumin (mg/dL) Mean (SD) 3.1 (0.57) 3.4 (0.53) 0.073
  CRP (mg/dL) Mean (SD) 7.40 (6.397) 5.98 (6.194) 0.139
Pseudomembrane g N (%) 10/26 (38.5) 2/5 (40.0)  
  1. A+B+, tcdA-positive tcdB-positive strain; A-B+, tcdA-negative tcdB-positive strain; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular accident; ICU, intensive care unit; Fr, frequency; CDI, Clostridium difficile infection; WBC, white blood cell; CRP, C-reactive protein.
  2. a From Fisher’s exact test for categorical variables or the Mann–Whitney U-test for continuous variables.
  3. b Defined as age >60 years.
  4. c Defined as temperature >38.3°C.
  5. d Defined as albumin level <2.5 mg/dL.
  6. e Defined as a WBC count >15,000 cells/mm.3
  7. f Severity scores >2 points were regarded as severe CDI.
  8. g Denominator comprises patients examined by endoscopy.