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Table 1 Clinical characteristics of patients with benign 3rd and 6th nerve palsy post-immunization

From: Recurrent 6th nerve palsy in a child following different live attenuated vaccines: case report

Authors Age/Gender/Side of paralysis Vaccine Type CN Time-post Vaccine Investigations Outcome
Werner et al.[5] 1 yr 3 mths/F/L MMR VI 10 days CT Brain Resolved over 3 months
  0 yr 8 mths/F/L DPT VI 6 weeks Nil Resolved over 6 months
   DPT Booster VI 3mths Nil Resolved over 2 months
McCormick et al.[7] 1 yr 1 mth/F/L MMR VI 1 week FBE, CRP, Anti-Nuclear Antibody (ANA), Measles and mumps serum titers, Anti-Mitochondrial antibody, blood cultures, serum rotavirus titer Resolved over 8 weeks
      Feces culture for parasites and C difficile  
      CT Brain  
Leidermann et al.[8] 1 yr 5 mths/M/R Influenza VI 3 weeks MRI Brain (T1, T2, Flair) Initial 10–20 degree incomitant esotropia with limitation of abduction
       12 weeks – 10 degree esotropia in R gaze
       7 months – residual motility deficit
Sturm et al.[3] 6 mths/M/R DPT, Polio, Hib VI 6 months MRI Brain Resolved at 5 days
Mahoney et al.[9] 1 yr 8 mths/M/L DPT, Hib VI 3 weeks MRI, AchRab Improving but incomplete
  2 yr 7 mths/M/L VZV VI 2.5 weeks   
Manzotti et al.[10] 20mths/M/L MMR III 3 weeks FBE, UEC Resolved at 20 days
      CMV, EBV, HSV,  
      VZV, Parvo B19, Influenza, Parainfluenza, RSV titers  
      Electroencephalography, MRI brain  
Chan et al.[11] 1 yr 5 mths/M/R Edmonston Measles III 2 weeks FBE, UEC, ESR, blood sugar level, CSF for protein, glucose, viral, bacterial, Blood cultures, Serum measles titer Resolved at 2 months
      Skull x-ray, electroencephalography, CT Brain  
      PPD Tuberculin Skin test  
      Intravenous Pyelogram (IVP)  
      Bone marrow aspirate  
  1. FBE full blood examination, UEC urea, electrolytes, creatinine, CRP C-reactive protein, CT computed tomography, MRI magnetic resonance imaging, CMV cytomegalovirus, EBV Epstein-Barr virus, HSV herpes simplex virus, VZV varicella zoster virus, RSV respiratory syncytial virus, DTPdiphtheria-tetanus –pertussis; MMR measles-mumps-rubella; Hib Haemophilus influenzae type b, AchRab acetylcholine receptor antibody testing.