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Table 4 Accuracy of antigens in diagnosing TB disease when used in combinations.

From: Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting

Antigen

combination

Resubstitution Classification Matrix

Leave-one-out Cross validation

Wilks lambda

f

P-value

 

% TB cases

% HHCs

Total %

% TB cases

% HHCs

   

ESAT-6/CFP-10

Rv2624c Rv2389c

86.7

(13/15)

73.3

(11/15)

80.0

73.3

(11/15)

73.3

(11/15)

0.59

18.3

0.0002

ESAT-6/CFP-10

Rv2624c Rv0867c

86.7

(13/15)

80.0

(12/15)

83.3

73.3

(11/15)

80.0

(12/15)

0.60

17.5

0.0002

ESAT-6/CFP-10

Rv2624c Rv1009

73.3

(11/15)

73.3

(11/15)

73.3

66.7 (10/15)

66.7 (10/15)

0.62

16.3

0.0004

Rv2032

Rv2624c Rv0867c

80.0 (12/15)

78.6 (11/14)

79.3

80.0 (12/15)

71.4 (10/14)

0.39

38.7

< 0.0001

Rv2032

Rv2624c

Rv2389c

86.7 (13/15)

78.6 (11/15)

82.7

86.7 (13/15)

64.3

(9/14)

0.39

39.3

< 0.0001

Rv2032

Rv2624c

Rv1009

86.7 (13/15)

71.4 (10/14)

79.3

86.7

(13/15)

64.3

(9/14)

0.41

36.1

< 0.0001

ESAT-6/CFP-10

Rv2032 Rv2389c

80.0 (12/15)

71.4

(10/14)

75.9

80.0

(12/15)

64.3

(9/14)

0.61

15.9

0.0005

ESAT-6/CFP-10

Rv2032 Rv0867c

80.0

(12/15)

78.6

(11/14)

79.3

73.3

(11/15)

71.4

(10/14)

0.62

15.6

0.0005

ESAT-6/CFP-10

Rv2032 Rv1009

73.3 (11/15)

71.4 (10/14)

72.4

73.3

(11/15)

64.3

(9/14)

0.63

14.5

0.0008

ESAT-6/CFP-10

Rv2032 Rv2624c

60.0

(9/15)

64.3 (9/14)

62.1

53.3

(8/15)

64.3

(9/14)

0.67

12.5

0.0015

  1. Abilities of combinations of antigens to discriminate between TB disease and no TB in General Discriminant Analysis models after supernatants were re-evaluated with the Quantiferon TB Gold ELISA. In each case, effect df = 1, error df = 25