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Table 4 Accuracy of antigens in diagnosing TB disease when used in combinations.

From: Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting

Antigen
combination
Resubstitution Classification Matrix Leave-one-out Cross validation Wilks lambda f P-value
  % TB cases % HHCs Total % % TB cases % HHCs    
ESAT-6/CFP-10
Rv2624c Rv2389c
86.7
(13/15)
73.3
(11/15)
80.0 73.3
(11/15)
73.3
(11/15)
0.59 18.3 0.0002
ESAT-6/CFP-10
Rv2624c Rv0867c
86.7
(13/15)
80.0
(12/15)
83.3 73.3
(11/15)
80.0
(12/15)
0.60 17.5 0.0002
ESAT-6/CFP-10
Rv2624c Rv1009
73.3
(11/15)
73.3
(11/15)
73.3 66.7 (10/15) 66.7 (10/15) 0.62 16.3 0.0004
Rv2032
Rv2624c Rv0867c
80.0 (12/15) 78.6 (11/14) 79.3 80.0 (12/15) 71.4 (10/14) 0.39 38.7 < 0.0001
Rv2032
Rv2624c
Rv2389c
86.7 (13/15) 78.6 (11/15) 82.7 86.7 (13/15) 64.3
(9/14)
0.39 39.3 < 0.0001
Rv2032
Rv2624c
Rv1009
86.7 (13/15) 71.4 (10/14) 79.3 86.7
(13/15)
64.3
(9/14)
0.41 36.1 < 0.0001
ESAT-6/CFP-10
Rv2032 Rv2389c
80.0 (12/15) 71.4
(10/14)
75.9 80.0
(12/15)
64.3
(9/14)
0.61 15.9 0.0005
ESAT-6/CFP-10
Rv2032 Rv0867c
80.0
(12/15)
78.6
(11/14)
79.3 73.3
(11/15)
71.4
(10/14)
0.62 15.6 0.0005
ESAT-6/CFP-10
Rv2032 Rv1009
73.3 (11/15) 71.4 (10/14) 72.4 73.3
(11/15)
64.3
(9/14)
0.63 14.5 0.0008
ESAT-6/CFP-10
Rv2032 Rv2624c
60.0
(9/15)
64.3 (9/14) 62.1 53.3
(8/15)
64.3
(9/14)
0.67 12.5 0.0015
  1. Abilities of combinations of antigens to discriminate between TB disease and no TB in General Discriminant Analysis models after supernatants were re-evaluated with the Quantiferon TB Gold ELISA. In each case, effect df = 1, error df = 25